EC Explorer
[browse EC tree] - [search]
EC 1.4.3.22 Details
show Brenda entryEC number
1.4.3.22
Accepted name
diamine oxidase
Reaction
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
Other name(s)
amine oxidase (ambiguous),
amine oxidase (copper-containing) (ambiguous),
CAO (ambiguous),
Cu-containing amine oxidase (ambiguous),
copper amine oxidase (ambiguous),
diamine oxidase (ambiguous),
diamino oxhydrase (ambiguous),
histaminase,
histamine deaminase (incorrect),
semicarbazide-sensitive amine oxidase (incorrect),
SSAO (incorrect)
Systematic name
histamine:oxygen oxidoreductase (deaminating)
Comment
A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 (primary-amine oxidase) but unlike EC 1.4.3.4 (monoamine oxidase), they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.
History
created 2007 (EC 1.4.3.6 created 1961, part-incorporated 2008)
back to topEC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.3.9 created 1972, deleted 1984 1.4.3.17 created 2000, deleted 2003 1.4.3.18 proposed 2000 1.97.1.5 created 2000 deleted 2001 1.97.1.6 created 2000 deleted 2001 1.97.1.7 created 2000, deleted 2001
