EC Explorer
[browse EC tree] - [search]
EC 1.1.5.10 Details
EC number
1.1.5.10
Accepted name
D-2-hydroxyacid dehydrogenase (quinone)
Reaction
(R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol
Other name(s)
(R)-2-hydroxy acid dehydrogenase,
(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase,
D-lactate dehydrogenase (ambiguous)
Systematic name
(R)-2-hydroxyacid:quinone oxidoreductase
Comment
The enzyme from mammalian kidney contains one mole of FAD per mole of enzyme.(R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors.
History
created 2014
EC Tree
1.1.5.1 created 1983, deleted 2002