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EC 1.10.5.1 Details
EC number
1.10.5.1
Accepted name
ribosyldihydronicotinamide dehydrogenase (quinone)
Reaction
1-(β-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(β-D-ribofuranosyl)nicotinamide + a quinol
Other name(s)
NRH:quinone oxidoreductase 2,
NQO2,
NAD(P)H:quinone oxidoreductase-2 (misleading),
QR2,
quinone reductase 2,
N-ribosyldihydronicotinamide dehydrogenase (quinone),
NAD(P)H:quinone oxidoreductase2 (misleading)
Systematic name
1-(β-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase
CAS registry number
667919-86-0
Comment
A flavoprotein. Unlike EC 1.6.5.2, NAD(P)H dehydrogenase (quinone), this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the estrogens 17β-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor [2]. This enzyme can catalyse both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced [3].
History
created 2005 as EC 1.10.99.2, transferred 2015 to EC 1.10.5.1
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