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EC 5.4.3.9 Details

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EC number

5.4.3.9

Accepted name

glutamate 2,3-aminomutase

Reaction

L-glutamate = 3-aminopentanedioate

Systematic name

L-glutamate 2,3-aminomutase

Comment

This enzyme is a member of the ’AdoMet radical’ (radical SAM) family. It contains pyridoxal phosphate and a [4Fe-4S] cluster, which is coordinated by 3 cysteines and binds an exchangeable S-adenosyl-L-methionine molecule. During the reaction cycle, the AdoMet forms a 5′-deoxyadenosyl radical, which is regenerated at the end of the reaction.

History

created 2012

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.99 With unknown physiological acceptors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

5.1 Racemases and epimerases

5.2 cis-trans-Isomerases

5.3 Intramolecular oxidoreductases

5.4 Intramolecular transferases

5.4.1 Transferring acyl groups

5.4.2 Phosphotransferases (phosphomutases)

5.4.3 Transferring amino groups

5.4.3.1 created 1972, deleted 1976

5.4.3.2 lysine 2,3-aminomutase

5.4.3.3 lysine 5,6-aminomutase

5.4.3.4 D-lysine 5,6-aminomutase

5.4.3.5 D-ornithine 4,5-aminomutase

5.4.3.6 tyrosine 2,3-aminomutase

5.4.3.7 leucine 2,3-aminomutase

5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase

5.4.3.9 glutamate 2,3-aminomutase

5.4.3.10 phenylalanine aminomutase (L-β-phenylalanine forming)

5.4.3.11 phenylalanine aminomutase (D-β-phenylalanine forming)

5.4.4 Transferring hydroxy groups

5.4.99 Transferring other groups

5.5 Intramolecular lyases

5.6 Isomerases altering macromolecular conformation

5.99 Other isomerases

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Release 2023.1 (January 2023)