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EC 1.2.7.3 Details
EC number
1.2.7.3
Accepted name
2-oxoglutarate synthase
Reaction
2-oxoglutarate + CoA + 2 oxidized ferredoxin = succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
Other name(s)
2-ketoglutarate ferredoxin oxidoreductase,
2-oxoglutarate:ferredoxin oxidoreductase,
KGOR,
2-oxoglutarate ferredoxin oxidoreductase,
2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)
Systematic name
2-oxoglutarate:ferredoxin oxidoreductase (decarboxylating)
CAS registry number
37251-05-1
Comment
The enzyme contains thiamine diphosphate and two [4Fe-4S] clusters. Highly specific for 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).
History
created 1972, modified 2005
EC Tree
1.2.7.9 created 2003, deleted 2005