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EC 1.2.5.1 Details
show Brenda entryEC number
1.2.5.1
Accepted name
pyruvate dehydrogenase (quinone)
Reaction
pyruvate + ubiquinone + H2O = acetate + CO2 + ubiquinol
Other name(s)
pyruvate dehydrogenase (ambiguous),
pyruvic dehydrogenase (ambiguous),
pyruvic (cytochrome b1) dehydrogenase (incorrect),
pyruvate:ubiquinone-8-oxidoreductase,
pyruvate oxidase (ambiguous),
pyruvate dehydrogenase (cytochrome) (incorrect)
Systematic name
pyruvate:ubiquinone oxidoreductase
Comment
Flavoprotein (FAD) [1]. This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone [2,3]. Does not accept menaquinone. Activity is greatly enhanced by lipids [4,5,6]. Requires thiamine diphosphate [7]. The enzyme can also form acetoin [8].
History
created 2010
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.6.1 created 1961, deleted 2002 1.6.6.2 created 1961, deleted 2002 1.6.6.3 created 1961, deleted 2002 1.6.6.4 created 1961, deleted 2002 1.6.6.5 created 1961, deleted 1964 1.6.6.6 created 1961, deleted 2002 1.6.6.7 created 1961, deleted 2002 1.6.6.8 created 1965, deleted 2002 1.6.6.10 created 1972, deleted 2002 1.6.6.11 created 1972, deleted 2002 1.6.6.12 created 1989, deleted 2002 1.6.6.13 created 1989, deleted 2002
