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EC 1.14.11.39 Details
EC number
1.14.11.39
Accepted name
L-asparagine hydroxylase
Reaction
L-asparagine + 2-oxoglutarate + O2 = (2S,3S)-3-hydroxyasparagine + succinate + CO2
Other name(s)
L-asparagine 3-hydroxylase,
AsnO
Systematic name
L-asparagine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Comment
Requires Fe2+. The enzyme is only able to hydroxylate free L-asparagine. It is not active toward D-asparagine. The β-hydroxylated asparagine produced is incorporated at position 9 of the calcium-dependent antibiotic (CDA), an 11-residue non-ribosomally synthesized acidic lipopeptide lactone.
History
created 2013
EC Tree
1.14.11.5 created 1972, deleted 1976