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EC 1.17.4.5 Details

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EC number

1.17.4.5

Accepted name

vitamin-K-epoxide reductase (warfarin-insensitive)

Reaction

3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol

Systematic name

3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase

CAS registry number

97089-80-0

Comment

Vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)].

History

created 1989 as EC 1.1.4.2, transferred 2014 to EC 1.17.4.5

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.6.1 created 1961, deleted 2002

1.6.6.2 created 1961, deleted 2002

1.6.6.3 created 1961, deleted 2002

1.6.6.4 created 1961, deleted 2002

1.6.6.5 created 1961, deleted 1964

1.6.6.6 created 1961, deleted 2002

1.6.6.7 created 1961, deleted 2002

1.6.6.8 created 1965, deleted 2002

1.6.6.9 trimethylamine-N-oxide reductase

1.6.6.10 created 1972, deleted 2002

1.6.6.11 created 1972, deleted 2002

1.6.6.12 created 1989, deleted 2002

1.6.6.13 created 1989, deleted 2002

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.17.1 With NAD⁺ or NADP⁺ as acceptor

1.17.2 With a cytochrome as acceptor

1.17.3 With oxygen as acceptor

1.17.4 With a disulfide as acceptor

1.17.4.1 ribonucleoside-diphosphate reductase

1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)

1.17.4.3 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive)

1.17.4.5 vitamin-K-epoxide reductase (warfarin-insensitive)

1.17.5 With a quinone or similar compound as acceptor

1.17.7 With an iron-sulfur protein as acceptor

1.17.8 With a flavin as acceptor

1.17.9 With a copper protein as acceptor

1.17.98 With other, known, physiological acceptors

1.17.99 With unknown physiological acceptors

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.20.1 With NAD⁺ or NADP⁺ as acceptor

1.20.2 With a cytochrome as acceptor

1.20.4 With disulfide as acceptor

1.20.4.1 arsenate reductase (glutathione/glutaredoxin)

1.20.4.2 methylarsonate reductase

1.20.4.3 mycoredoxin

1.20.4.4 arsenate reductase (thioredoxin)

1.20.9 With a copper protein as acceptor

1.20.98 With other, known, physiological acceptors

1.20.99 With unknown physiological acceptors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)