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EC 2.7.8.33 Details
EC number
2.7.8.33
Accepted name
UDP-N-acetylglucosamine—undecaprenyl-phosphate N-acetylglucosaminephosphotransferase
Reaction
UDP-N-acetyl-α-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Other name(s)
UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase,
WecA,
WecA transferase,
UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase,
GlcNAc-P-P-Und synthase,
GPT (ambiguous),
TagO,
UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase,
UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetylglucosaminephosphotransferase
Systematic name
UDP-N-acetyl-α-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-α-D-glucosaminephosphotransferase
Comment
This enzyme catalyses the synthesis of N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol, an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components. The enzyme also initiates the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide in certain Escherichia coli strains, including K-12 [2] and of teichoic acid in certain Gram-positive bacteria [4].
History
created 2011
EC Tree
2.7.8.16 created 1983, deleted 1986