EC Explorer
[browse EC tree] - [search]
EC 2.3.2.2 Details
EC number
2.3.2.2
Accepted name
γ-glutamyltransferase
Reaction
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid
Other name(s)
glutamyl transpeptidase,
α-glutamyl transpeptidase,
γ-glutamyl peptidyltransferase,
γ-glutamyl transpeptidase (ambiguous),
γ-GPT,
γ-GT,
γ-GTP,
L-γ-glutamyl transpeptidase,
L-γ-glutamyltransferase,
L-glutamyltransferase,
GGT (ambiguous),
γ-glutamyltranspeptidase (ambiguous)
Systematic name
(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase
CAS registry number
9046-27-9
Comment
The mammlian enzyme is part of the cell antioxidant defense mechanism. It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels. The protein also has EC 3.4.19.13 (glutathione hydrolase) activity [3-4]. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions [3-4].
History
created 1972, modified 1976, modified 2011
EC Tree