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EC 2.3.2.5 Details
EC number
2.3.2.5
Accepted name
glutaminyl-peptide cyclotransferase
Reaction
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3
Other name(s)
glutaminyl-tRNA cyclotransferase,
glutaminyl cyclase,
glutaminyl-transfer ribonucleate cyclotransferase
Systematic name
L-glutaminyl-peptide γ-glutamyltransferase (cyclizing)
CAS registry number
37257-21-9
Comment
Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.
History
created 1972, modified 1990
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