EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
6.3.5.3 | phosphoribosylformylglycinamidine synthase |
hepatoma cell |
16, 20, 44, 7787, 7777, 3924A, 5123tc |
1664 |
4.1.1.32 | phosphoenolpyruvate carboxykinase (GTP) |
hepatoma cell |
Reuber H365 hepatoma cells |
4364 |
4.1.1.32 | phosphoenolpyruvate carboxykinase (GTP) |
hepatoma cell |
- |
4365 |
2.1.2.5 | glutamate formimidoyltransferase |
hepatoma cell |
DU249 chicken hepatoma cells, contain p60 but no measurable formiminotransferase activity, may be due to the low expression of p60 |
34325 |
4.3.1.4 | formimidoyltetrahydrofolate cyclodeaminase |
hepatoma cell |
- |
34325 |
4.3.1.4 | formimidoyltetrahydrofolate cyclodeaminase |
hepatoma cell |
isoform of the formiminotransferase cyclodeaminase enzyme complex |
34325 |
4.3.1.4 | formimidoyltetrahydrofolate cyclodeaminase |
hepatoma cell |
HepG2 cell line |
34328 |
3.1.2.6 | hydroxyacylglutathione hydrolase |
hepatoma cell |
Kirkman-Robbins hepatoma |
37413 |
3.1.2.6 | hydroxyacylglutathione hydrolase |
hepatoma cell |
Morris hepatoma cells 5123S |
37413 |
3.1.3.42 | [glycogen-synthase-D] phosphatase |
hepatoma cell |
- |
94864 |
2.7.1.105 | 6-phosphofructo-2-kinase |
hepatoma cell |
resembles muscle enzyme |
94932 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
hepatoma cell |
- |
94932 |
3.1.4.11 | phosphoinositide phospholipase C |
hepatoma cell |
rapidly growing hepatoma 3924A |
135125 |
3.5.1.6 | beta-ureidopropionase |
hepatoma cell |
- |
172058 |
3.5.2.2 | dihydropyrimidinase |
hepatoma cell |
- |
172058 |
3.5.4.10 | IMP cyclohydrolase |
hepatoma cell |
- |
172163 |
1.1.1.205 | IMP dehydrogenase |
hepatoma cell |
- |
347916 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
hepatoma cell |
- |
349006 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
hepatoma cell |
- |
392128 |
1.14.11.16 | peptide-aspartate beta-dioxygenase |
hepatoma cell |
highly expressed in 4 of 10 hepatocarcinomas, 10-fold activity increase |
439254 |
2.1.1.17 | phosphatidylethanolamine N-methyltransferase |
hepatoma cell |
enzyme form PEMT2 is absent in hepatoma cells growing exponentially in vivo. Both PEMT2 and mRNA appears when cells enter the stationary phase of tumor growth |
485189 |
2.1.1.17 | phosphatidylethanolamine N-methyltransferase |
hepatoma cell |
PEMT2 protein decreases in preneoplastic nodules and virtually disappears in hepatocellular carcinoma |
485195 |
2.3.1.48 | histone acetyltransferase |
hepatoma cell |
tissue culture cell, HTC cells |
487078 |
2.3.2.2 | gamma-glutamyltransferase |
hepatoma cell |
primary and Yoshida ascites (AH 13) |
487912 |
2.3.2.2 | gamma-glutamyltransferase |
hepatoma cell |
azo dye-induced |
487913 |
2.4.1.101 | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
diethylnitrosamine- or dimethylaminoazobenzene-induced hepatoma, Morris 5123D hepatoma or AH-109A, solid or ascitic |
488363 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
- |
488370, 637308, 638223, 638224, 638227, 736507 |
2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase |
hepatoma cell |
- |
489333 |
2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase |
hepatoma cell |
DAB-induced hepatoma |
489333 |
2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase |
hepatoma cell |
expression in hepatoma tissues and their surrounding tissues and in tissues with chronic disease, overview |
489339 |
2.4.1.69 | type 1 galactoside alpha-(1,2)-fucosyltransferase |
hepatoma cell |
e.g. hepatoma H35 cells, the enzyme is induced during early stages of chemical hepatocarcinogenesis in parenchymal cells of Fischer 344 rats fed a diet supplemented with 0.03% N-2-acetylaminofluorene, undetectable in normal liver tissue |
489357 |
2.5.1.22 | spermine synthase |
hepatoma cell |
- |
489869 |
2.7.10.1 | receptor protein-tyrosine kinase |
hepatoma cell |
- |
490387 |
2.7.11.24 | mitogen-activated protein kinase |
hepatoma cell |
- |
491741 |
2.5.1.18 | glutathione transferase |
hepatoma cell |
- |
637909, 637921 |
2.4.2.31 | NAD+-protein-arginine ADP-ribosyltransferase |
hepatoma cell |
- |
638116 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
low activity |
638223 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
primary, about 100fold increased activity compared to normal liver tissue |
638223 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
7721 cells, activity during cell-cycle |
638226 |
2.7.1.137 | phosphatidylinositol 3-kinase |
hepatoma cell |
Fao hepatoma cells |
640913 |
2.7.1.48 | uridine/cytidine kinase |
hepatoma cell |
hepatoma 3924A cells, 2fold increase in activity during early log phase of prolifration |
641653 |
2.7.4.8 | guanylate kinase |
hepatoma cell |
Morris 7793 or Dunning |
642686 |
2.7.7.19 | polynucleotide adenylyltransferase |
hepatoma cell |
- |
642938 |
2.7.7.19 | polynucleotide adenylyltransferase |
hepatoma cell |
Morris hepatoma tumor cells 3924A |
642946, 642951 |
2.7.7.19 | polynucleotide adenylyltransferase |
hepatoma cell |
Morris hepatomas 3924A and 7777, relative lack of poly(A) polymerase activity is partly due to decreased level of this enzyme in the tumors, but largely due to the nonavailability of the primer-binding sites on the solubilized enzyme and to occupation of the available binding sites with an ineffective primer |
642967 |
2.8.1.1 | thiosulfate sulfurtransferase |
hepatoma cell |
only about 20% of the activity of normal liver |
645502 |
2.8.2.1 | aryl sulfotransferase |
hepatoma cell |
- |
645675 |
3.2.1.113 | mannosyl-oligosaccharide 1,2-alpha-mannosidase |
hepatoma cell |
- |
646574 |
3.2.1.114 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase |
hepatoma cell |
- |
646574 |
3.2.1.130 | glycoprotein endo-alpha-1,2-mannosidase |
hepatoma cell |
clone 9 |
-, 646732 |
3.1.3.9 | glucose-6-phosphatase |
hepatoma cell |
- |
649729, 750010 |
3.1.2.4 | 3-hydroxyisobutyryl-CoA hydrolase |
hepatoma cell |
46% reduced activity compared to healthy cells |
650865 |
7.2.2.9 | P-type Cu2+ transporter |
hepatoma cell |
Hep3B |
656023 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
hepatoma cell |
- |
657750, 688952 |
2.4.1.90 | N-acetyllactosamine synthase |
hepatoma cell |
Hep-G2 cells |
658123 |
2.5.1.21 | squalene synthase |
hepatoma cell |
- |
658266, 738940 |
2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase |
hepatoma cell |
- |
660642, 660896, 674730, 760485 |
2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase |
hepatoma cell |
PDK4 |
660642 |
6.3.5.4 | asparagine synthase (glutamine-hydrolysing) |
hepatoma cell |
- |
661295, 675566 |
2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase |
hepatoma cell |
Fao cell line |
661301 |
2.7.11.1 | non-specific serine/threonine protein kinase |
hepatoma cell |
- |
491119, 661422, 661900 |
2.7.10.2 | non-specific protein-tyrosine kinase |
hepatoma cell |
- |
490349, 661445, 661461 |
2.7.11.10 | IkappaB kinase |
hepatoma cell |
- |
662516 |
2.7.1.1 | hexokinase |
hepatoma cell |
type II isozyme |
662531 |
2.4.1.65 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase |
hepatoma cell |
- |
662544 |
3.1.3.9 | glucose-6-phosphatase |
hepatoma cell |
hepatitis virus-induced hepatocellular carcinoma |
664672 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
hepatoma cell |
- |
664865 |
2.7.11.30 | receptor protein serine/threonine kinase |
hepatoma cell |
- |
665532 |
3.5.3.15 | protein-arginine deiminase |
hepatoma cell |
strong expression |
666311 |
3.2.1.51 | alpha-L-fucosidase |
hepatoma cell |
not detected in adjacent tissue |
667006 |
7.6.2.4 | ABC-type fatty-acyl-CoA transporter |
hepatoma cell |
- |
667429 |
2.7.1.91 | sphingosine kinase |
hepatoma cell |
- |
671356, 673271 |
6.1.1.19 | arginine-tRNA ligase |
hepatoma cell |
- |
672090 |
6.3.4.16 | carbamoyl-phosphate synthase (ammonia) |
hepatoma cell |
- |
672441, 672452, 673597 |
2.1.1.5 | betaine-homocysteine S-methyltransferase |
hepatoma cell |
- |
673003 |
1.14.11.16 | peptide-aspartate beta-dioxygenase |
hepatoma cell |
- |
673915, 675183, 675861 |
6.2.1.3 | long-chain-fatty-acid-CoA ligase |
hepatoma cell |
- |
662463, 673484, 674910 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
- |
675946, 759648 |
2.7.11.13 | protein kinase C |
hepatoma cell |
constitutively active isozyme PKCdelta |
676029 |
2.4.2.10 | orotate phosphoribosyltransferase |
hepatoma cell |
OPRT is involved in early events of invasion of hepatocellular carcinoma cells |
676296 |
6.3.1.2 | glutamine synthetase |
hepatoma cell |
- |
676918 |
1.8.1.9 | thioredoxin-disulfide reductase |
hepatoma cell |
- |
677195 |
4.1.1.17 | ornithine decarboxylase |
hepatoma cell |
- |
677508 |
3.1.4.12 | sphingomyelin phosphodiesterase |
hepatoma cell |
- |
678142, 678957 |
3.1.8.1 | aryldialkylphosphatase |
hepatoma cell |
- |
678489 |
3.4.13.18 | cytosol nonspecific dipeptidase |
hepatoma cell |
- |
679269 |
3.4.21.1 | chymotrypsin |
hepatoma cell |
- |
680927 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
hepatoma cell |
- |
681878 |
4.2.1.22 | cystathionine beta-synthase |
hepatoma cell |
reduced cystathionine beta-synthase |
682533 |
3.4.24.24 | gelatinase A |
hepatoma cell |
- |
683442 |
2.3.1.26 | sterol O-acyltransferase |
hepatoma cell |
- |
486677, 684882 |
1.4.3.13 | protein-lysine 6-oxidase |
hepatoma cell |
- |
684931 |
1.1.1.1 | alcohol dehydrogenase |
hepatoma cell |
- |
686331 |
2.5.1.6 | methionine adenosyltransferase |
hepatoma cell |
- |
686924, 686926 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
hepatoma cell |
overexpression of HO-1 |
-, 687147 |
1.11.1.9 | glutathione peroxidase |
hepatoma cell |
- |
688957 |
2.7.10.2 | non-specific protein-tyrosine kinase |
hepatoma cell |
HCC cell |
691651 |
3.1.4.50 | glycosylphosphatidylinositol phospholipase D |
hepatoma cell |
- |
691854 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
hepatoma cell |
- |
692267 |
2.7.11.12 | cGMP-dependent protein kinase |
hepatoma cell |
- |
693879 |