Information on EC 1.1.1.1 - alcohol dehydrogenase

for references in articles please use BRENDA:EC1.1.1.1
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

EC NUMBER
COMMENTARY hide
1.1.1.1
-
RECOMMENDED NAME
GeneOntology No.
alcohol dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
a secondary alcohol + NAD+ = a ketone + NADH + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
3-methylbutanol biosynthesis (engineered)
-
-
acetaldehyde biosynthesis I
-
-
acetylene degradation
-
-
butanol and isobutanol biosynthesis (engineered)
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-
chitin degradation to ethanol
-
-
ethanol degradation I
-
-
ethanol degradation II
-
-
heterolactic fermentation
-
-
L-1,2-propanediol degradation
-
-
L-isoleucine degradation II
-
-
L-leucine degradation III
-
-
L-methionine degradation III
-
-
L-phenylalanine degradation III
-
-
L-tryptophan degradation V (side chain pathway)
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L-tyrosine degradation III
-
-
L-valine degradation II
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mixed acid fermentation
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-
noradrenaline and adrenaline degradation
-
-
phenylethanol biosynthesis
-
-
phytol degradation
-
-
pyruvate fermentation to ethanol I
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-
pyruvate fermentation to ethanol II
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pyruvate fermentation to ethanol III
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pyruvate fermentation to isobutanol (engineered)
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-
salidroside biosynthesis
-
-
serotonin degradation
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superpathway of fermentation (Chlamydomonas reinhardtii)
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ethanol fermentation
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leucine metabolism
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methionine metabolism
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-
phenylalanine metabolism
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propanol degradation
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tryptophan metabolism
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tyrosine metabolism
-
-
valine metabolism
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Glycolysis / Gluconeogenesis
-
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Fatty acid degradation
-
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Glycine, serine and threonine metabolism
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Tyrosine metabolism
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alpha-Linolenic acid metabolism
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Chloroalkane and chloroalkene degradation
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Naphthalene degradation
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Retinol metabolism
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Metabolism of xenobiotics by cytochrome P450
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Drug metabolism - cytochrome P450
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Metabolic pathways
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Biosynthesis of secondary metabolites
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Microbial metabolism in diverse environments
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
alcohol:NAD+ oxidoreductase
A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
CAS REGISTRY NUMBER
COMMENTARY hide
9031-72-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
2 soluble isozymes
-
-
Manually annotated by BRENDA team
2 soluble isozymes
-
-
Manually annotated by BRENDA team
Aeropyrum pernix ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
KU 1309
-
-
Manually annotated by BRENDA team
KU 1309
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
fragment; CCTCC M203011
UniProt
Manually annotated by BRENDA team
gene chy1186
-
-
Manually annotated by BRENDA team
gene chy1186
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
japonica. ADH-1, ADH-2, ADH-3 and ADH-An
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
var. Cantalupensis
-
-
Manually annotated by BRENDA team
KNK10702
-
-
Manually annotated by BRENDA team
KNK10702
-
-
Manually annotated by BRENDA team
alcohol dehydrogenase 2
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
gene GmAdh2
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
3 isoenzymes
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
cationic pyrazole-sensitive isoenzyme, anodic pyrazole-sensitive isoenzyme and cathionic pyrazole-in sensitive isoenzyme
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
FGSC2489
SwissProt
Manually annotated by BRENDA team
FGSC2489
-
-
Manually annotated by BRENDA team
gene adh3
-
-
Manually annotated by BRENDA team
gene adh3
-
-
Manually annotated by BRENDA team
i.e. Pichia angusta, HpADH3 is not the major ADH in strain DL-1, gene ADH3
UniProt
Manually annotated by BRENDA team
i.e. Pichia angusta, HpADH3 is not the major ADH in strain DL-1, gene ADH3
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain DSM 50106, stereoselective enzyme
-
-
Manually annotated by BRENDA team
probable alcohol dehydrogenase
UniProt
Manually annotated by BRENDA team
probable alcohol dehydrogenase
UniProt
Manually annotated by BRENDA team
DSM44514
-
-
Manually annotated by BRENDA team
strain DSM44541
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-
Manually annotated by BRENDA team
-
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-
Manually annotated by BRENDA team
pyrazole-insensitive isoenzyme and pyrazole-sensitive isoenzyme
-
-
Manually annotated by BRENDA team
Sporotrichum pulverulentum
-
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-
Manually annotated by BRENDA team
strain DSM1617
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-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
ATCC 27502
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Manually annotated by BRENDA team
strain DSM 1728
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
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Manually annotated by BRENDA team
-
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-
Manually annotated by BRENDA team
3 isoenzymes
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Manually annotated by BRENDA team
-
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-
Manually annotated by BRENDA team
-
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-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
methylglyoxal accumulation leads to G2-phase arrest by affecting cell growth, ROS production, viability, differentiation, and virulence. Phenotypes of enzyme-deficient cells, overview
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(-)-carvone + NADH + H+
? + NAD+
show the reaction diagram
1% activity compared to cyclohexanone
-
-
?
(1S,3S)-3-methylcyclohexanol + NAD+
(rac)-3-methylcyclohexanone + NADH + H+
show the reaction diagram
125% activity compared to cyclohexanol
163% activity compared to cyclohexanone
-
r
(2E)-2-methylpent-2-enal + NADPH + H+
(2E)-2-methylpent-2-en-1-ol + NADP+
show the reaction diagram
41.5% of the activity with (2E)-but-2-enal, yield 95% after 12 h
-
-
?
(2E)-3,7-dimethylocta-2,6-dienal + NADPH + H+
(2E)-3,7-dimethylocta-2,6-dien-1-ol + NADP+
show the reaction diagram
37.4% of the activity with (2E)-but-2-enal, yield 87% after 12 h
-
-
?
(2E)-but-2-en-1-ol + NADP+
(2E)-but-2-enal + NADPH + H+
show the reaction diagram
-
-
-
r
(2E)-but-2-enal + NADPH + H+
(2E)-but-2-en-1-ol + NADP+
show the reaction diagram
yield 96% after 12 h
-
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r
(2E)-dec-2-enal + NADPH + H+
(2E)-dec-2-en-1-ol + NADP+
show the reaction diagram
16.7% of the activity with (2E)-but-2-enal, yield 91% after 12 h
-
-
?
(2E)-hex-2-enal + NADPH + H+
(2E)-hex-2-en-1-ol + NADP+
show the reaction diagram
41.7% of the activity with (2E)-but-2-enal, yield 98% after 12 h
-
-
?
(2E)-oct-2-enal + NADPH + H+
(2E)-oct-2-en-1-ol + NADP+
show the reaction diagram
30.2% of the activity with (2E)-but-2-enal, yield 69% after 12 h
plus 27% oct-2-enyl ester
-
?
(6S)-5,6-dihydro-6-methyl-4H-thieno[2,3b]thiopyran-4-one-7,7-dioxide + NADH + H+
(4S,6S)-5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3b]thiopyran-7,7-dioxide + NAD+
show the reaction diagram
-
-
-
-
-
(E)-hex-2-en-1-ol + NAD+
(E)-hex-2-en-1-one + NADH
show the reaction diagram
(R)-1-indanol + NAD+
1-indanone + NADH + H+
show the reaction diagram
-
-
-
r
(R)-1-indanol + NAD+
?
show the reaction diagram
62% of activity compared to (S)-1-indanol
-
-
?
(R)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
(R)-2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
(R)-2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
(R)-2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
(R)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
(R)-2-phenylpropanol + NAD+
(R)-2-phenylpropanal + NADH + H+
show the reaction diagram
(R)-3-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
(R)-alpha-tetralol + NAD+
?
show the reaction diagram
58% of activity compared to (S)-1-indanol
-
-
?
(R)-alpha-tetralol + NAD+
alpha-tetralone + NADH + H+
show the reaction diagram
-
-
-
r
(R,S)-2-methylbutan-1-ol + NAD+
(R,S)-2-methyl-butan-1-one + NADH + H+
show the reaction diagram
(S)-(+)-1-indanol + NAD+
indanone + NADH + H+
show the reaction diagram
-
-
-
-
?
(S)-1-indanol + NAD+
1-indanone + NADH + H+
show the reaction diagram
(S)-1-indanol + NAD+
?
show the reaction diagram
-
-
-
?
(S)-1-phenyl-2-propanol + NAD+
phenylacetone + NADH + H+
show the reaction diagram
-
9% activity compared to cyclohexanone
-
r
(S)-1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
show the reaction diagram
-
-
-
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r
(S)-2-butanol + NAD+
2-butanone + NADH
show the reaction diagram
-
-
-
-
r
(S)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
(S)-2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
-
331% of the activity with 2-propanol
-
-
r
(S)-2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
-
38% of the activity with 2-propanol
-
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r
(S)-2-methylbutan-1-ol + NAD+
(S)-2-methyl-butanal + NADH + H+
show the reaction diagram
(S)-2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
(S)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
(S)-2-pentanol + NAD+
?
show the reaction diagram
11% of activity compared to (S)-1-indanol
-
-
?
(S)-2-phenylpropanol + NAD+
(S)-2-phenylpropanal + NADH + H+
show the reaction diagram
-
156% of the activity with 2-phenylethanol
-
-
?
(S)-4-phenylbutan-2-ol + NAD+
benzylacetone + NADH + H+
show the reaction diagram
-
3% activity compared to cyclohexanone
-
r
(S)-alpha-tetralol + NAD+
?
show the reaction diagram
12% of activity compared to (S)-1-indanol
-
-
?
(S)-alpha-tetralol + NAD+
alpha-tetralone + NADH + H+
show the reaction diagram
(S)-heptan-2-ol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
-
-
-
r
(S)-pentan-2-ol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
-
-
-
r
(S)-perillylalcohol + NAD+
(S)-perillaldehyde + NADH + H+
show the reaction diagram
52% activity compared to cyclohexanol
-
-
?
(Z)-hex-2-en-1-ol + NAD+
(Z)-hex-2-en-1-one + NADH
show the reaction diagram
-
9.7% of the activity with ethanol
-
-
?
1,1-dichloroacetone + NADH + H+
1,1-dichloropropan-2-ol + NADH
show the reaction diagram
-
1078% of the activity with phenyl trifluoromethyl ketone
-
-
?
1,2-butanediol + NAD+
?
show the reaction diagram
1,2-butanediol + NAD+
? + NADH + H+
show the reaction diagram
-
-
-
?
1,2-hexanediol + NAD+
?
show the reaction diagram
-
20% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,2-pentanediol + NAD+
?
show the reaction diagram
-
12% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,2-propanediol + NAD+
?
show the reaction diagram
1,2-propanediol + NAD+
hydroxyacetone + NADH
show the reaction diagram
-
-
-
-
?
1,2-propanediol + NAD+
hydroxyacetone + NADH + H+
show the reaction diagram
-
-
-
-
?
1,3-butanediol + NAD+
?
show the reaction diagram
-
39% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,3-propanediol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
1,3-propanediol + NAD+
?
show the reaction diagram
1,3-propanediol + NAD+
? + NADH
show the reaction diagram
-
7% of the activity with ethanol
-
-
?
1,4-butanediol + NAD+
? + NADH + H+
show the reaction diagram
best substrate in oxidation reaction
-
-
?
1,5-pentanediol + NAD+
? + NADH + H+
show the reaction diagram
1-(3-bromophenyl)ethanol + NAD+
1-(3-bromophenyl)ethanone + NADH + H+
show the reaction diagram
315% of the activity with 1-phenylethanol
-
-
?
1-(3-chlorophenyl)ethanol + NAD+
1-(3-chlorophenyl)ethanone + NADH + H+
show the reaction diagram
205% of the activity with 1-phenylethanol
-
-
?
1-(4'-chlorophenyl)ethanol + NAD+
1-(4'-chlorophenyl)ethanone + NADH + H+
show the reaction diagram
-
26% of the activity with (S)-(-)-1-phenylethanol
-
-
?
1-(4'-fluorophenyl)ethanol + NAD+
1-(4'-fluorophenyl)ethanone + NADH + H+
show the reaction diagram
-
45% of the activity with (S)-1-phenylethanol
-
-
r
1-(4-bromophenyl)ethanol + NAD+
1-(4-bromophenyl)ethanone + NADH + H+
show the reaction diagram
167% of the activity with 1-phenylethanol
-
-
?
1-(4-chlorophenyl)ethanol + NAD+
1-(4-chlorophenyl)ethanone + NADH + H+
show the reaction diagram
151% of the activity with 1-phenylethanol
-
-
?
1-(4-fluorophenyl)ethanol + NAD+
1-(4-fluorophenyl)ethanone + NADH + H+
show the reaction diagram
1-(4-methylphenyl)ethanol + NAD+
1-(4-methylphenyl)ethanone + NADH + H+
show the reaction diagram
189% of the activity with 1-phenylethanol
-
-
?
1-(p-tolyl)-ethanol + NAD+
1-(4-methylphenyl)ethanone + NADH + H+
show the reaction diagram
19% activity compared to cyclohexanol
26% activity compared to cyclohexanone
-
?
1-butanal + NADH + H+
1-butanol + NAD+
show the reaction diagram
-
-
-
-
r
1-butanol + 2 NAD+ + H2O
butanoic acid + 2 NADH + 2 H+
show the reaction diagram
1-butanol + NAD+
butanal + NADH
show the reaction diagram
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
1-chloro-5-acetylfuro[2,3-c]pyridine + NADH + H+
1-chloro-5-(1-hydroxyethyl)furo[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
1-decalone + NADH + H+
decahydronaphthalen-1-ol + NAD+
show the reaction diagram
85% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
1-decanol + NAD+
decanal + NADH + H+
show the reaction diagram
1-dodecanol + NAD+
dodecanal + NADH
show the reaction diagram
1-heptanol + NAD+
1-heptanal + NADH + H+
show the reaction diagram
-
-
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
show the reaction diagram
1-heptanol + NAD+
heptanol + NADH + H+
show the reaction diagram
-
56% of the activity with 2-propanol, in the reverse reaction 755% of the activity with phenyl trifluoromethyl ketone
-
-
r
1-hexanal + NADH + H+
1-hexanol + NAD+
show the reaction diagram
-
-
-
-
r
1-hexanol + 2 NAD+ + H2O
hexanoic acid + 2 NADH + 2 H+
show the reaction diagram
1-hexanol + NAD+
1-hexanal + NADH + H+
show the reaction diagram
1-hexanol + NAD+
?
show the reaction diagram
-
15% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
1-hydroxy-2-butanone + NADH + H+
butane-1,2-diol + NAD+
show the reaction diagram
-
59% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
1-hydroxymethyl-6-methylpyrene + NAD+
1-formyl-6-methylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
1-hydroxymethyl-8-methylpyrene + NAD+
1-formyl-8-methylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
1-hydroxymethylpyrene + NAD+
1-formylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
1-indanol + NAD+
1-indanone + NADH + H+
show the reaction diagram
1-indanone + NADH + H+
(S)-1-indanol + NAD+
show the reaction diagram
1-indanone + NADH + H+
1-indanol + NAD+
show the reaction diagram
-
-
-
-
r
1-nonanol + NAD+
nonanal + NADH + H+
show the reaction diagram
1-octanol + 2 NAD+ + H2O
octanoic acid + 2 NADH + 2 H+
show the reaction diagram
1-octanol + 2 NADP+ + H2O
octanoic acid + 2 NADPH + 2 H+
show the reaction diagram
-
-
-
r
1-octanol + NAD+
1-octanal + NADH + H+
show the reaction diagram
-
6% of activity with N-benzyl-3-pyrrolidinol
-
-
?
1-octanol + NAD+
octanal + NADH
show the reaction diagram
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
1-pentanol + NAD+
1-pentanal + NADH + H+
show the reaction diagram
1-pentanol + NAD+
pentanal + NADH + H*
show the reaction diagram
-
8% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
1-phenyl-1,2-ethanediol + NAD+
1-phenyl-2-propanone + NADH + H+
show the reaction diagram
1% activity compared to cyclohexanol
-
-
r
1-phenyl-1,2-propandione + NADH + H+
1-phenyl-2-hydroxy-1-propanone + NAD+
show the reaction diagram
-
146% of the activity with 2,2,2-trifluoroacetophenone
-
-
r
1-phenyl-1,2-propanedione + NADH
?
show the reaction diagram
about 25% of the activity compared to isatin
-
-
?
1-phenyl-1,2-propanedione + NADH + H+
?
show the reaction diagram
1-phenyl-1-propanol + NAD+
1-phenyl-1-propanone + NADH + H+
show the reaction diagram
-
59% of the activity with (S)-(-)-1-phenylethanol
-
-
?
1-phenyl-1-propanol + NAD+
1-phenylpropan-1-one + NADH + H+
show the reaction diagram
-
59% of the activity with (S)-1-phenylethanol
-
-
r
1-phenyl-1-propanol + NAD+
?
show the reaction diagram
-
31% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-phenyl-2-butanone + NADH + H+
1-phenylbutan-2-ol + NAD+
show the reaction diagram
1-phenyl-2-propanol + NAD+
1-phenyl-2-propanone + NADH + H+
show the reaction diagram
1-phenyl-2-propanone + NADH + H+
(S)-1-phenyl-2-propanol + NAD+
show the reaction diagram
-
-
-
-
-
1-phenyl-3-butanone + NADH + H+
1-phenylbutan-3-ol + NAD+
show the reaction diagram
-
353% of the activity with phenyl trifluoromethyl ketone
-
-
?
1-phenylethanol + NAD+
1-phenylethanone + NADH
show the reaction diagram
1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
show the reaction diagram
1-phenylethanol + NAD+
acetophenone + NADH + H+
show the reaction diagram
-
1% activity compared to cyclohexanone
-
?
1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
show the reaction diagram
-
-
-
?
1-propanol + NAD+
propanal + NADH
show the reaction diagram
-
-
-
-
?
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
1-propanol + NAD+
propanaldehyde + NADH + H+
show the reaction diagram
11-cis-retinal + NADH + H+
11-cis-retinol + NAD+
show the reaction diagram
-
-
-
-
?
11-cis-retinol + NAD+
11-cis-retinal + NADH
show the reaction diagram
12-hydroxydodecanoate + NAD+
12-oxododecanoic acid + NADH
show the reaction diagram
12-hydroxylauric acid methyl ester + NAD+
12-oxolauric acid methyl ester + NADH + H+
show the reaction diagram
-
-
product is a key intermediate for biobased polyamide 12 production
-
?
12-oxolauric acid methyl ester + NADH + H+
12-hydroxylauric acid methyl ester + NAD+
show the reaction diagram
-
-
-
-
?
13-cis-retinal + NADH + H+
13-cis-retinol + NAD+
show the reaction diagram
-
-
-
-
?
13-cis-retinol + NAD+
13-cis-retinal + NADH
show the reaction diagram
16-hydroxyhexadecanoate + NAD+
16-oxohexadecanoic acid + NADH
show the reaction diagram
-
-
-
-
?
17beta-hydroxyetiocholan-3-one + NAD+
ethiocholan-3,17-dione + NADH
show the reaction diagram
-
-
-
-
?
2',3',4',5',6'-pentafluoroacetophenone + NADH + H+
1-(2,3,4,5,6-pentafluorophenyl)ethanol + NAD+
show the reaction diagram
45% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2,2'-dichlorobenzil + NADH + H+
1,2-bis(2-chlorophenyl)-2-hydroxyethanone + NAD+
show the reaction diagram
-
-
-
?
2,2,2-trichloroethanol + NAD+
trichloroacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
2,2,2-trifluoro-1-phenylethanone + propan-2-ol
(1R)-2,2,2-trifluoro-1-phenylethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 99% enantiomeric excess
-
?
2,2,2-trifluoroacetophenone + NADH
2,2,2-trifluoro-1-phenylethanol + NAD+
show the reaction diagram
about 35% of the activity compared to isatin
-
-
?
2,2,2-trifluoroacetophenone + NADH + H+
(R)-alpha-(trifluoromethyl)benzyl alcohol + NAD+
show the reaction diagram
2,2,2-trifluoroacetophenone + NADH + H+
2,2,2-trifluoro-1-phenylethanol + NAD+
show the reaction diagram
2,2,2-trifluoroacetophenone + NADPH + H+
(R)-2,2,2-trifluoro-1-phenylethanol + NADP+
show the reaction diagram
180% of the activity with acetoin
-
-
r
2,2-dichloroacetophenone + NADH + H+
2,2-dichloro-1-phenylethanol + NAD+
show the reaction diagram
2,2-difluoro-1-phenylethanone + propan-2-ol
(1R)-2,2-difluoro-1-phenylethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 94% enantiomeric excess
-
?
2,3'-dichloroacetophenone + NADH + H+
1-(2,3-dichlorophenyl)ethanol + NAD+
show the reaction diagram
-
67% of the activity with phenyl trifluoromethyl ketone
-
-
?
2,3'-dichloroacetophenone + NADH + H+
2-chloro-1-(3-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
2,3-butanediol + H2O
?
show the reaction diagram
-
-
-
?
2,3-butanediol + NAD+
?
show the reaction diagram
-
83% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
2,3-butanediol + NAD+
acetoin + NADH + H+
show the reaction diagram
2,3-butanedione + NADH + H+
?
show the reaction diagram
-
activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
2,3-pentanedione + NADH
? + NADH
show the reaction diagram
-
5.5% of the activity with acetaldehyde
-
-
?
2,4-pentanediol + NAD+
?
show the reaction diagram
2-(3,5-dimethylphenyl)propanal + NADH + H+
(S)-2-(3,5-dimethylphenyl)propanol + NAD+
show the reaction diagram
2-(3-benzoylphenyl)propanal + NADH + H+
(S)-2-(3-benzoylphenyl)propanol + NAD+
show the reaction diagram
2-(3-fluorobiphenyl-4-yl)propanal + NADH + H+
(S)-2-(3-(fluoro)biphenyl-4-yl)propanol + NAD+
show the reaction diagram
2-(3-phenoxyphenyl)propanal + NADH + H+
(S)-2-((3-phenoxy)phenyl)propanol + NAD+
show the reaction diagram
2-(4-isobutylphenyl)propanal + NADH + H+
(S)-2-(4-isobutylphenyl)propanol + NAD+
show the reaction diagram
2-(4-trifluoromethylphenyl)propanal + NADH + H+
(S)-2-(4-trifluoromethyl)phenylpropanol + NAD+
show the reaction diagram
-
18 h, 55% yield, 98% enantiomeric excess
-
-
?
2-(6-methoxynaphthalen-2-yl)propanal + NADH + H+
(S)-2-(6-methoxynaphthalen-2-yl)propan-1-ol + NAD+
show the reaction diagram
-
18 h, 96% yield, 98% enantiomeric excess
-
-
?
2-(naphthalen-1-yl)propanal + NADH + H+
(S)-2-(naphthalen-1-yl)propanol + NAD+
show the reaction diagram
-
18 h, 90% yield, 80% enantiomeric excess
-
-
?
2-(naphthalen-2-yl)propanal + NADH + H+
(S)-2-(naphthalen-2-yl)propanol + NAD+
show the reaction diagram
-
18 h, 57% yield, 94% enantiomeric excess
-
-
?
2-acetylcyclohexanone + NADH + H+
2-acetylcyclohexanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylcyclopentanone + NADH + H+
2-acetylcyclopentanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylfuran + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylpyridine + NADH + H+
(R)-1-(2-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylpyrrole + NADH + H+
1-(1H-pyrrol-2-yl)ethanol + NAD+
show the reaction diagram
-
70% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-acetylpyrrole + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylthiazole + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylthiophene + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-aminoethanol + NAD+
?
show the reaction diagram
-
-
-
?
2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
2-butanone + NADH + H+
2-butanol + NAD+
show the reaction diagram
2-butanone + NADH + H+
butan-2-ol + NAD+
show the reaction diagram
-
2.8fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
2-butanone + NADPH + H+
butan-2-ol + NADP+
show the reaction diagram
12.1% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-butene-1-ol + NAD+
? + NADH
show the reaction diagram
2-chloroacetophenone + NADH + H+
1-(2-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
low activity
-
-
r
2-chlorocyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
3% activity compared to cyclohexanone
-
-
?
2-decalone + NADH + H+
? + NAD+
show the reaction diagram
28% activity compared to cyclohexanone
-
-
?
2-decanol + NAD+
2-decanone + NADH + H+
show the reaction diagram
weak activity
-
-
r
2-decanone + NADH
(S)-2-decanol + NAD+ + H+
show the reaction diagram
-
-
92% enantiomeric excess
-
?
2-deoxy-D-ribose + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
2-ethoxyethanol + NAD+
2-ethoxyacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
2-ethylhexan-1-ol + NAD+
2-ethylhexanal + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
weak activity
-
-
?
2-fluoro-1-(4-chlorophenyl)ethanone + propan-2-ol
(1R)-2-fluoro-1-(4-chlorophenyl)ethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 98% enantiomeric excess
-
?
2-fluoro-1-(4-fluorophenyl)ethanone + propan-2-ol
(1R)-2-fluoro-1-(4-fluorophenyl)ethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 97% enantiomeric excess
-
?
2-fluoro-1-(4-iodophenyl)ethanone + propan-2-ol
(1R)-2-fluoro-1-(4-iodophenyl)ethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 99% enantiomeric excess
-
?
2-fluoro-1-phenylethanone + propan-2-ol
(1R)-2-fluoro-1-phenylethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 99% enantiomeric excess
-
?
2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
2-heptanol + NAD+
heptan-2-one + NADH + H+
show the reaction diagram
62% of the activity with 1-phenylethanol
-
-
?
2-heptanone + NADH
(S)-2-heptanol + NAD+ + H+
show the reaction diagram
-
-
79% enantiomeric excess
-
?
2-heptanone + NADH + H+
(R)-2-heptanol + NAD+
show the reaction diagram
-
229% of the activity with phenyl trifluoromethyl ketone
99% enantiomeric excess
-
?
2-heptanone + NADPH + H+
heptan-2-ol + NADP+
show the reaction diagram
6.8% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
2-hexanone + NADH
(S)-2-hexanol + NAD+ + H+
show the reaction diagram
-
-
37% enantiomeric excess
-
?
2-hexanone + NADH + H+
2-hexanol + NAD+
show the reaction diagram
-
-
-
-
r
2-hexanone + NADH + H+
?
show the reaction diagram
-
activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
2-hexanone + NADH + H+
hexan-2-ol + NAD+
show the reaction diagram
-
50.4fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
2-hexanone + NADPH + H+
hexan-2-ol + NADP+
show the reaction diagram
5.9% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
show the reaction diagram
2.4% of the activity with NADPH
-
-
?
2-hydroxyacetophenone + NADPH + H+
(S)-1-phenyl-1,2-ethanediol + NADP+
show the reaction diagram
-
-
-
?
2-hydroxymethylpyrene + NAD+
2-formylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
2-mercaptoethanol + NAD+
?
show the reaction diagram
2-methoxybenzaldehyde + NADH + H+
2-methoxybenzylalcohol + NAD+
show the reaction diagram
-
13% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
2-methoxybenzyl alcohol + NAD+
2-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
25% of the activity with (S)-(-)-1-phenylethanol
-
-
?
2-methoxyethanol + NAD+
2-methoxyacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
r
2-methyl-2,4-pentanediol + NAD+
?
show the reaction diagram
1% activity compared to cyclohexanol
-
-
?
2-methylbutan-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
2-methylbutyraldehyde + NADH + H+
2-methylbutanol + NAD+
show the reaction diagram
-
1.4% of the activity with acetaldehyde
-
-
?
2-methylcyclohexanone + NADH + H+
2-methylcyclohexanol + NAD+
show the reaction diagram
13% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
46% activity compared to cyclohexanone
-
-
?
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH
show the reaction diagram
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH + H+
show the reaction diagram
2-methylpropionaldehyde + NADH + H+
2-methylpropanal + NAD+
show the reaction diagram
-
3.3% of the activity with acetaldehyde
-
-
?
2-nitrobenzaldehyde + NADH + H+
(2-nitrophenyl)methanol + NAD+
show the reaction diagram
-
33% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-nitrobenzaldehyde + NADH + H+
2-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
low activity
-
-
r
2-nonanol + NAD+
2-nonanone + NADH + H+
show the reaction diagram
weak activity
-
-
r
2-nonanone + NADH
(S)-2-nonanol + NAD+ + H+
show the reaction diagram
-
-
95% enantiomeric excess
-
?
2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
2-octanone + NADH
(S)-2-octanol + NAD+ + H+
show the reaction diagram
-
-
92% enantiomeric excess
-
?
2-octanone + NADH + H+
2-octanol + NAD+
show the reaction diagram
-
-
-
-
r
2-octanone + NADPH + H+
octan-2-ol + NADP+
show the reaction diagram
11.9% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-oxo-3-methylpentane + NADH
3-methylpentan-2-ol + NAD+
show the reaction diagram
2-oxo-3-phenylpropane + NADH
2-hydroxy-3-phenylpropane + NAD+
show the reaction diagram
2-oxo-4-methylpentane + NADH
4-methylpentan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
2-oxo-butyric acid + NADH + H+
2-hydroxybutyric acid + NAD+
show the reaction diagram
-
15% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-oxohexane + NADH
2-hydroxyhexane + NAD+
show the reaction diagram
-
-
-
-
?
2-oxopentane + NADH
2-pentanol + NAD+
show the reaction diagram
-
-
-
-
?
2-oxopentanoate + NADH + H+
2-hydroxypentanoate + NAD+
show the reaction diagram
-
low activity
-
-
r
2-oxopropanal + NADH + H+
? + NAD+
show the reaction diagram
328% of the activity with acetoin
-
-
r
2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
2-pentanone + NADH
(S)-2-pentanol + NAD+ + H+
show the reaction diagram
-
-
60% enantiomeric excess
-
?
2-pentanone + NADH
pentan-2-ol + NAD+
show the reaction diagram
-
-
-
r
2-pentanone + NADH + H+
2-pentanol + NAD+
show the reaction diagram
2-pentanone + NADPH + H+
pentan-2-ol + NADP+
show the reaction diagram
11.9% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-phenylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
2-phenylethanol + NAD+
2-phenylethanone + NADH + H+
show the reaction diagram
57% activity compared to cyclohexanol
-
-
r
2-phenylethanol + NAD+
phenylacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
2-phenylpropanal + NADH + H+
(S)-2-phenylpropanol + NAD+
show the reaction diagram
-
18 h, 74% yield, 98% enantiomeric excess
-
-
?
2-propanol + NAD(P)+
acetone + NAD(P)H
show the reaction diagram
2-propanol + NAD+
2-propanone + NADH
show the reaction diagram
2-propanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
2-propanol + NAD+
aceton + NADH + H+
show the reaction diagram
-
-
irreversible, no measurable activity with acetone
-
ir
2-propanol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
2-propanol + NAD+
propanone + NADH + H+
show the reaction diagram
-
-
-
-
r
2-[3-(2-phenyl-1,3-dioxolan-2-yl)phenyl]propanal + NADH + H+
(S)-2-(3-(2-phenyl-1,3-dioxolan-2-yl)phenyl)propanol + NAD+
show the reaction diagram
-
18 h, 95% yield, 61% enantiomeric excess
-
-
?
3',4'-dimethoxyphenylacetone + NADH + H+
1-(3,4-dimethoxyphenyl)propan-2-ol + NAD+
show the reaction diagram
-
24% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-bromoacetophenone + NADH + H+
1-(3-bromophenyl)ethanol + NAD+
show the reaction diagram
-
151% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-chloroacetophenone + NADH + H+
1-(3-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
70% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-methoxyacetophenone + NADH + H+
1-(3-methoxyphenyl)ethanol + NAD+
show the reaction diagram
-
51% of the activity with phenyl trifluoromethyl ketone
-
-
?
3,3,5-trimethylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
3,4-dihydro-retinol + NAD+
3,4-dihydro-retinal
show the reaction diagram
-
-
-
-
r
3,4-dimethylbenzyl alcohol + NAD+
3,4-dimethylbenzaldehyde + NADH + H+
show the reaction diagram
45% activity compared to cyclohexanol
-
-
r
3,4-hexanedione + NADH + H+
?
show the reaction diagram
-
77% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
3,4-methylenedioxyphenyl acetone + NADH
(S)-(3,4-methylenedioxyphenyl)-2-propanol + NAD+ + H+
show the reaction diagram
-
-
-
-
-
3,5-dimethylcyclohexanol + NAD+
3,5-dimethylcyclohexanone + NADH + H+
show the reaction diagram
1% activity compared to cyclohexanol
-
-
r
3-acetylpyridine + NADH + H+
(R)-1-(3-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
3-acetylpyridine + NADH + H+
1-pyridin-3-ylethanol + NAD+
show the reaction diagram
-
7.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
3-aminobenzyl alcohol + NAD+
3-aminobenzaldehyde + NADH + H+
show the reaction diagram
8% activity compared to cyclohexanol
-
-
r
3-bromobenzyl alcohol + NAD+
3-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-bromobenzylalcohol + NAD+
3-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-butene-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-chloro-2-butanone + NADH + H+
3-chlorobutan-2-ol + NAD+
show the reaction diagram
-
151% of the activity with phenyl trifluoromethyl ketone
-
-
?
3-chlorobenzaldehyde + NADH + H+
3-chlorobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
3-heptanol + NAD+
3-heptanone + NADH + H+
show the reaction diagram
-
93% of the activity with 2-propanol
-
-
r
3-methoxy-1-phenylpropan-1-one + NADH
3-methoxy-1-phenylpropan-1-ol + NAD+
show the reaction diagram
-
-
-
-
?
3-methoxybenzaldehyde + NADH + H+
3-methoxybenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
3-methoxybenzaldehyde + NADH + H+
3-methoxybenzylalcohol + NAD+
show the reaction diagram
-
14% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
3-methoxybenzyl alcohol + NAD+
3-methoxybenzaldehyde + NADH + H+
show the reaction diagram
3-methoxybenzylalcohol + NAD+
3-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-methyl-1-butanol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-methyl-2-cyclohexenone + NADH + H+
? + NAD+
show the reaction diagram
1% activity compared to cyclohexanone
-
-
?
3-methylbutan-1-ol + NAD+
3-methyl-butan-1-one + NADH + H+
show the reaction diagram
3-methylbutan-2-ol + NAD+
3-methylbutan-2-one + NADH
show the reaction diagram
-
R-(-)-3-methylbutan-2-ol and S-(+)-3-methylbutan-2-ol
-
-
?
3-methylbutan-2-one + NADH
3-methylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
3-methylbutan-2-one + NADH + H+
3-methyl-2-butanol + NAD+
show the reaction diagram
-
-
-
-
r
3-methylbutan-2-one + NADH + H+
3-methylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
3-methylbutanal + NAD+
? + NADH + H+
show the reaction diagram
3-methylbutanol + NAD+
3-methylbutanone + NADH + H+
show the reaction diagram
133% activity compared to cyclohexanol
-
-
r
3-methylbutanol + NAD+
? + NADH
show the reaction diagram
3-methylbutyraldehyde + NADH + H+
3-methylbutanol + NAD+
show the reaction diagram
-
2.9% of the activity with acetaldehyde
-
-
?
3-methylcyclohexanol + NAD+
3-methylcyclohexanone + NADH
show the reaction diagram
-
-
-
-
r
3-methylcyclohexanol + NAD+
3-methylcyclohexanone + NADH + H+
show the reaction diagram
14% of activity compared to (S)-1-indanol
-
-
?
3-methylcyclohexanol + NAD+
?
show the reaction diagram
10% of the activity compared to isoborneol
-
-
?
3-methylcyclohexanone + NADH
3-methylcyclohexanol + NAD+
show the reaction diagram
3-methylcyclohexanone + NADH + H+
3-methylcyclohexanol + NAD+
show the reaction diagram
33% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
3-methylphenylethyl alcohol + NAD+
?
show the reaction diagram
64% activity compared to cyclohexanol
-
-
?
3-nitroacetophenone + NADH + H+
1-(3-nitrophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
3-nitrobenzaldehyde + NADH + H+
3-nitrobenzyl alcohol + NAD+
show the reaction diagram
3-oxo-5beta-androstan-17beta-ol + NADH
3beta,17beta-dihydroxy-5beta-androstane + NAD+
show the reaction diagram
3-oxoheptane + NADH
3-hydroxyheptane + NAD+
show the reaction diagram
-
-
-
-
?
3-pentanol + NAD+
3-pentanone + NADH + H+
show the reaction diagram
3-pentanone + NADH
pentan-3-ol + NAD+
show the reaction diagram
-
-
-
r
3-pentanone + NADPH + H+
pentan-3-ol + NADP+
show the reaction diagram
7.1% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
3-penten-2-one + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
3-phenyl-1-propanol + NAD+
3-phenyl-1-propanone + NADH
show the reaction diagram
3-phenyl-2-propen-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-phenylpropanol + NAD+
3-phenylpropanal + NADH + H+
show the reaction diagram
-
135% of the activity with 2-phenylethanol
-
-
?
3-phenylpropionaldehyde + NADH
3-phenylpropan-1-ol + NAD+
show the reaction diagram
-
1218% of the activity with phenyl trifluoromethyl ketone
-
-
?
3-phenylpropionaldehyde + NADH + H+
3-phenylpropanol + NAD+
show the reaction diagram
-
6.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
3-pyridylcarbinol + NAD+
pyridine-3-carbaldehyde + NADH
show the reaction diagram
-
-
-
-
?
3beta,12alpha-dihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta,17beta-dihydroxy-5beta-androstane + NAD+
5beta-androstan-3,17dione + NADH
show the reaction diagram
-
-
-
-
?
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta,7alpha-dihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta-hxdroxy-5alpha-cholanoate + NAD+
3-oxo-5alpha-cholanoate + NADH
show the reaction diagram
-
-
-
-
?
3beta-hydroxy-5beta-androstan-17-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
3beta-hydroxy-5beta-cholanoate + NAD+
3-oxo-5beta-cholanoate + NADH
show the reaction diagram
-
-
-
-
?
4'-bromoacetophenone + NADH + H+
1-(4-bromophenyl)ethanol + NAD+
show the reaction diagram
-
77% of the activity with phenyl trifluoromethyl ketone
-
-
?
4'-chloroacetophenone + NADH + H+
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
60% of the activity with phenyl trifluoromethyl ketone
-
-
?
4'-chlorobutyrophenone + NADH + H+
1-(4-chlorophenyl)butan-1-ol + NAD+
show the reaction diagram
-
10% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
4-acetylpyridine + NADH + H+
(R)-1-(4-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-acetylpyridine + NADH + H+
1-pyridin-4-ylethanol + NAD+
show the reaction diagram
-
64.5fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
4-bromobenzyl alcohol + NAD+
4-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
4-bromobenzylalcohol + NAD+
4-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
4-carboxybenzaldehyde + NADH + H+
4-carboxybenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-carboxybenzaldehyde + NADH + H+
4-carboxybenzylalcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-chloroacetophenone + NADH
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
4-chloroacetophenone + NADH + H+
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-chlorobenzaldehyde + NADH + H+
4-chlorobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
4-ethylcyclohexanol + NAD+
4-ethylcyclohexanone + NADH + H+
show the reaction diagram
60% activity compared to cyclohexanol
-
-
r
4-ethylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
22% activity compared to cyclohexanone
-
-
?
4-fluoroacetophenone + NADH + H+
1-(4-fluorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-hydroxy-2-butanone + NADH + H+
2,4-dihydroxybutane + NAD+
show the reaction diagram
-
26% of the activity with phenyl trifluoromethyl ketone
-
-
?
4-hydroxy-retinol + NAD+
4-oxo-retinal + NADH
show the reaction diagram
-
-
-
-
r
4-hydroxymethylpyrene + NAD+
4-formylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
4-hydroxynonenal + NADH + H+
4-hydroxynonenol + NAD+
show the reaction diagram
-
substrate of isozyme ADH4
-
-
r
4-methoxy-1-naphthaldehyde + NAD+
4-methoxy-1-naphthol + NADH + H+
show the reaction diagram
-
fluorogenic substrate of class I and II isozymes
-
-
?
4-methoxy-1-naphthaldehyde + NAD+
4-methoxy-1-naphthyl alcohol + NADH + H+
show the reaction diagram
-
substrate for class I ADH
-
-
?
4-methoxy-1-naphthaldehyde + NADH + H+
4-methoxynaphthalene-1-carbaldehyde + NAD+
show the reaction diagram
-
substrate for class I ADH
-
-
r
4-methoxybenzaldehyde + NADH + H+
4-methoxybenzyl alcohol + NAD+
show the reaction diagram
-
-
51% of the activity with butan-2-ol
-
?
4-methoxybenzaldehyde + NADH + H+
4-methoxybenzylalcohol + NAD+
show the reaction diagram
-
13% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
4-methoxybenzyl alcohol + NAD+
4-methoxybenzaldehyde + NADH + H+
show the reaction diagram
4-methoxybenzylalcohol + NAD+
4-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
4-methoxyphenylacetone + NADH
(2S)-1-(4-methoxyphenyl)propan-2-ol + NAD+ + H+
show the reaction diagram
-
-
-
-
?
4-methyl-1-pentanol + NAD+
4-methyl-1-pentanal + NADH
show the reaction diagram
4-methylcyclohexanol + NAD+
4-methylcyclohexanone + NADH + H+
show the reaction diagram
56% activity compared to cyclohexanol
-
-
r
4-methylcyclohexanone + NADH + H+
4-methylcyclohexanol + NAD+
show the reaction diagram
60% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
4-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
25% activity compared to cyclohexanone
-
-
?
4-methylpentan-2-one + NADH + H+
4-methyl-2-pentanol + NAD+
show the reaction diagram
-
-
-
-
r
4-nitrobenzaldehyde + NADH + H+
4-nitrobenzyl alcohol + NAD+
show the reaction diagram
4-nitrobenzaldehyde + NADH + H+
4-nitrobenzylalcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-nitrobenzyl alcohol + NAD+
4-nitrobenzaldehyde + NADH + H+
show the reaction diagram
94% activity compared to benzyl alcohol
-
-
?
4-nitrosodimethylaniline + NAD+
? + NADH + H+
show the reaction diagram
-
photometric assay substrate
-
-
?
4-phenylbutan-2-one + NADH
4-phenylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
5-acetyl-7-chlorofuro[2,3-c]pyridine + NADH + H+
5-(1-hydroxyethyl)-7-chlorofuro[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
5-acetylfuro[2,3-c]pyridine + NADH + H+
5-(1-hydroxyethyl)furo[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
5-hydroxymethylfurfural + NADH + H+
(furan-2,5-diyl)dimethanol + NAD+
show the reaction diagram
5alpha-androstan-17beta-ol-3-one + NADH + H+
3beta,17beta-dihydroxy-5alpha-androstan + NAD+
show the reaction diagram
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH
show the reaction diagram
-
low activity
-
-
?
5beta-androstan-17beta-ol-3-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
5beta-androstan-3beta-ol-17-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
5beta-cholanic acid-3-one + NAD+
5beta-cholanic acid-3-ol + NAD+
show the reaction diagram
-
-
-
-
?
5beta-cholanic acid-3-one + NADH
5beta-cholanic acid-3-ol + NAD+
show the reaction diagram
-
low activity
-
-
?
5beta-pregnan-21-ol-3,20-dione hemisuccinate + NADH
5beta-pregnan-3,20,21-trione hemisuccinate + NADH
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3,20-dione + NADH
?
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3beta-ol-20-one + NAD+
5beta-pregnan-3,20-dione + NADH
show the reaction diagram
-
-
-
-
?
6-benzyloxy-3,5-dioxo-hexanoic acid ethyl ester + NADH + H+
(3R,5S)-6-benzyloxy-3,5-dihydroxy-hexanoic acid ethyl ester + NAD+
show the reaction diagram
-
-
-
-
-
6-methoxy-2-naphthaldehyde + NADH + H+
(6-methoxynaphthalen-2-yl)methanol + NAD+
show the reaction diagram
-
substrate for class II ADH
-
-
r
6-methoxy-2-naphthaldehyde + NADH + H+
6-methoxy-2-naphthyl alcohol + NAD+
show the reaction diagram
-
substrate for class II ADH
-
-
?
6-methoxy-2-naphthaldehyde + NADH + H+
6-methoxy-2-naphtol + NAD+
show the reaction diagram
-
class II isozyme, reductive activity
-
-
?
7-cis-retinol + NAD+
7-cis-retinal + NADH
show the reaction diagram
9-cis-retinol + NAD+
9-cis-retinal + NADH
show the reaction diagram
a primary alcohol + NAD+
an aldehyde + NADH + H+
show the reaction diagram
-
ADH3 is involved in multiple cellular pathways, as diverse as formaldehyde detoxification, retinoid metabolism and NO homeostasis, ADH3 is considered to play only a minor role in hepatic alcohol metabolism because ethanol concentrations rarely exceed 50 mM
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
acetaldehyde + NADH + H+
ethanol + NAD+ + H+
show the reaction diagram
acetaldehyde + NADPH + H+
ethanol + NADP+
show the reaction diagram
acetoin + NAD+
diacetyl + NADH
show the reaction diagram
18% of the activity with 2,3-butanediol
-
-
?
acetoin + NADH + H+
2,3-butanediol + NAD+
show the reaction diagram
-
-
-
r
acetoin + NADH + H+
3-hydroxy-2-butanol + NAD+
show the reaction diagram
-
-
-
-
r
acetoin + NADH + H+
butan-2,3-diol + NAD+
show the reaction diagram
-
-
-
?
acetone + NAD+ + H2O
? + NADH + H+
show the reaction diagram
about 5% of the activity with 1-octanol
-
-
r
acetone + NADH
isopropanol + NAD+
show the reaction diagram
acetone + NADH + H+
2-propanol + NAD+
show the reaction diagram
-
-
-
-
?
acetone + NADH + H+
propan-2-ol + NAD+
show the reaction diagram
-
1.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
acetone + NADPH + H+
propan-2-ol + NADP+
show the reaction diagram
14.7% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
acetophenone + NADH
(R)-alpha-phenyl ethanol + NAD+
show the reaction diagram
-
the enzyme exhibits high stereoselectivity in the desymmetrization of the prochiral ketone acetophenone, producing optically pure (R)-alpha-phenyl ethanol at high conversion
-
-
?
acetophenone + NADH + H+
(R)-1-phenylethanol + NAD+
show the reaction diagram
-
6% of the activity with phenyl trifluoromethyl ketone, in the reverse reaction 87% of the activity with 2-propanol
99% enantiomeric excess
-
?
acetophenone + NADH + H+
(S)-(-)-1-phenylethanol + NAD+
show the reaction diagram
-
more than 99% enantiomeric excess
-
-
r
acetophenone + NADH + H+
(S)-1-phenylethanol + NAD+
show the reaction diagram
-
-
99% enantiomeric excess
-
r
acetophenone + NADH + H+
1-phenylethanol + NAD+
show the reaction diagram
acetophenone + NADPH + H+
1-phenylethanol + NADP+
show the reaction diagram
5.1% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
acetylacetone + 2 NADH + 2 H+
2,4-pentanediol + 2 NAD+
show the reaction diagram
-
-
-
-
r
acetylacetone + NADH + H+
?
show the reaction diagram
-
63% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
acetylacetone + NADH + H+
acetophenone + NADH + H+
show the reaction diagram
1% activity compared to cyclohexanone
1% activity compared to cyclohexanone
-
r
acetylpyrazine + NADH + H+
(R)-1-(pyrazyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
alcohol + NAD+
aldehyde or ketone + NADH
show the reaction diagram
all-trans retinal + NADH + H+
all-trans retinol + NAD+
show the reaction diagram
26.8% of the activity with butan-1-ol
-
-
?
all-trans-retinal + NADH + H+
all-trans-retinol + NAD+
show the reaction diagram
-
-
-
-
?
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
allyl alcohol + NAD+
acrolein + NADH
show the reaction diagram
allyl alcohol + NAD+
prop-2-en-1-al + NADH
show the reaction diagram
allylalcohol + NAD+
prop-2-enal + NADH + H+
show the reaction diagram
-
-
-
?
alpha-ethyl benzoylformate + NADH + H+
ethyl (R)-(-)-mandelate + NAD+
show the reaction diagram
-
-
95% enantiomeric excess
-
r
alpha-methyl benzoylformate + NADH + H+
methyl (R)-mandelate + NAD+
show the reaction diagram
-
-
92% enantiomeric excess
-
r
alpha-tetralone + NADH + H+
(S)-alpha-tetralol + NAD+
show the reaction diagram
alpha-tetralone + NADH + H+
alpha-tetralol + NAD+
show the reaction diagram
-
-
-
-
r
anisaldehyde + NADH
anisic alcohol + NADH
show the reaction diagram
-
-
-
-
?
anisaldehyde + NADH + H+
anisic alcohol + NAD+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NADH
benzyl alcohol + NAD+
show the reaction diagram
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
show the reaction diagram
107% of the activity with (2E)-but-2-enal, yield 99% after 12 h
-
-
r
benzil + NADH + H+
(R)-benzoin + NAD+
show the reaction diagram
62% of the activity compared to 1-phenyl-1,2-propanedione. The enzyme catalyses the asymmetric reduction of benzil to (R)-benzoin with both excellent conversion (98%) and optical purity (98%) by way of an efficient in situ NADH-recycling system involving a second thermophilic ADH
-
-
?
benzoin + NADH + H+
1,2-diphenylethane-1,2-diol
show the reaction diagram
-
13% of activity with N-benzyl-3-pyrrolidinone
-
-
?
benzoylformic acid + NADPH + H+
mandelate + NADP+
show the reaction diagram
2.4% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
benzyl aclohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + acycloNADH + H+
show the reaction diagram
-
acycloNAD+ i.e. NAD+-analogue, where the nicotinamide ribosyl moiety has been replaced by the nicotinamide (2-hydroxyethoxy)methyl moiety
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
show the reaction diagram
-
-
-
r
benzylacetone + NADH + H+
4-phenylbutan-2-ol + NAD+
show the reaction diagram
benzylalcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
benzyloxycarbonyl-3-pyrrolidinone + NADH + H+
(S)-benzyloxycarbonyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
production with 99.6% enantiomeric excess
-
-
?
butan-1-ol + NAD+
butanal + acycloNADH + H+
show the reaction diagram
-
acycloNAD+ i.e. NAD+-analogue, where the nicotinamide ribosyl moiety has been replaced by the nicotinamide (2-hydroxyethoxy)methyl moiety
-
-
?
butan-1-ol + NAD+
butanal + NADH + H+
show the reaction diagram
butan-2,3-diol + NAD+
acetoin + NADH + H+
show the reaction diagram
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
butan-2-ol + NAD+
butanone + NADH + H+
show the reaction diagram
-
-
83% of the activity with butan-2-ol
-
?
butan-2-one + NADH
butan-2-ol + NAD+
show the reaction diagram
butanal + NADH
1-butanol + NAD+ + H+
show the reaction diagram
-
% of the activity with phenyl trifluoromethyl ketone
-
-
ir
butanal + NADH
n-butanol + NAD+
show the reaction diagram
butanal + NADH + H+
butan-1-ol + NAD+
show the reaction diagram
-
-
-
r
butanol + NAD+
1-butanal + NADH + H+
show the reaction diagram
butanol + NAD+
butanal + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
butanol + NAD+
butyraldehyde + NADH + H+
show the reaction diagram
butanol + NAD+
n-butanal + NADH
show the reaction diagram
-
-
-
?
butyraldehyde + NAD+
n-butanol + NADH + H+
show the reaction diagram
-
-
-
-
r
buty