2.7.1.113: deoxyguanosine kinase
This is an abbreviated version!
For detailed information about deoxyguanosine kinase, go to the full flat file.
Word Map on EC 2.7.1.113
-
2.7.1.113
-
deoxycytidine
-
mtdna
-
thymidine
-
hepatocerebral
-
deoxyribonucleoside
-
deoxynucleoside
-
ophthalmoplegia
-
sucla2
-
twinkle
-
9-beta-d-arabinofuranosylguanine
-
cladribine
-
c10orf2
-
nystagmus
-
2-chlorodeoxyadenosine
-
deoxyinosine
-
2.7.1.74
-
2-chloro-2'-deoxyadenosine
-
mngie
-
neurogastrointestinal
-
medicine
- 2.7.1.113
- deoxycytidine
- mtdna
- thymidine
-
hepatocerebral
- deoxyribonucleoside
- deoxynucleoside
- ophthalmoplegia
- sucla2
- twinkle
- 9-beta-d-arabinofuranosylguanine
- cladribine
- c10orf2
-
nystagmus
- 2-chlorodeoxyadenosine
- deoxyinosine
-
2.7.1.74
- 2-chloro-2'-deoxyadenosine
-
mngie
-
neurogastrointestinal
- medicine
Reaction
Synonyms
(dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, deoxyadenosine kinase/deoxyguanosine kinase, deoxyguanosine kinase, DG kinase, DGK, dGKase, DGUOK, kinase, deoxyguanosine (phosphorylating), NTP-deoxyguanosine 5'-phosphotransferase, nucleoside triphosphate: deoxyguanosine 5'-phosphotransferase
ECTree
2.7.1.113 deoxyguanosine kinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.1.113 - deoxyguanosine kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxyadenosine-3'-fluoro-3'-triphosphate + 2'-deoxyguanosine
2'-deoxyadenosine-3'-fluoro-3'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
-
-
-
?
2'-deoxyadenosine-3'-fluoroara-3'-triphosphate + 2'-deoxyguanosine
2'-deoxyadenosine-3'-fluoroara-3'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
low activity
-
-
?
2'-deoxyadenosine-3'-triphosphate + 2'-deoxyguanosine
2'-deoxyadenosine-3'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
-
-
-
?
3'-deoxyadenosine-2'-triphosphate + 2'-deoxyguanosine
3'-deoxyadenosine-2'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
-
-
-
?
3'-deoxyadenosine-3'-fluoro-2'-triphosphate + 2'-deoxyguanosine
3'-deoxyadenosine-3'-fluoro-2'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
-
-
-
?
3'-deoxyadenosine-3'-fluoroxylo-2'-triphosphate + 2'-deoxyguanosine
3'-deoxyadenosine-3'-fluoroxylo-2'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
-
-
-
?
ATP + 1-(2-deoxy-beta-D-ribofuranosyl)-7-iodoisocarbostyril
ADP + ?
-
4.4% of the activity with 2'-deoxyguanosine
-
-
?
ATP + 1-(2-deoxy-beta-D-ribofuranosyl)-isocarbostyril
ADP + ?
-
poor substrate, 1.1% of the activity with 2'-deoxyguanosine
-
-
?
ATP + 1-beta-D-arabinofuranosyladenine
ADP + 1-beta-D-arabinofuranosyladenine 5'-phosphate
-
-
-
?
ATP + 2',2'-difluorodeoxyguanosine
ADP + 2',2'-difluorodeoxyguanosine 5'-monophosphate
recombinant mitochondrial deoxyguanosine kinase, 147% of activity with deoxyguanosine
-
?
ATP + 2',2'-difluorodeoxyguanosine
ADP + 2',2'-difluorodeoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2',3'-dideoxyguanosine
ADP + 2',3'-dideoxyguanosine 5'-monophosphate
-
recombinant deoxyguanosine kinase, 14% of activity with deoxyguanosine
-
?
ATP + 2'-deoxyinosine
ADP + 2'-deoxyinosine 5'-phosphate
-
-
-
?
ATP + 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine
ADP + 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine 5'-monophosphate
-
recombinant mitochondrial deoxyguanosine kinase
-
?
ATP + 2-chloro-2'-arabinofluoro-2'-deoxyadenosine
ADP + 2-chloro-2'-arabinofluoro-2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2-chlorodeoxyadenosine
ADP + 2-chlorodeoxyadenosine 5'-monophosphate
-
-
-
-
?
ATP + 2-chlorodeoxyadenosine
ADP + 2-chlorodeoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2-fluoro-arabinosyl-adenine
ADP + 2-fluoro-arabinosyl-adenine 5'-monophosphate
-
recombinant mitochondrial deoxyguanosine kinase
-
?
ATP + 2-fluoroadenine-beta-D-arabinofuranoside
ADP + 2-fluoroadenine-beta-D-arabinofuranoside 5'-monophosphate
-
-
-
-
?
ATP + 3'-fluoro-2',3'-dideoxyguanosine
ADP + 3'-fluoro-2',3'-dideoxyguanosine 5'-monophosphate
-
recombinant deoxyguanosine kinase, 14% of activity with deoxyguanosine
-
?
ATP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine
ADP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine 5'-monophosphate
-
antiherpesvirus drug ganciclovir, recombinant mitochondrial deoxyguanosine kinase, 6% of activity with deoxyguanosine
-
?
ATP + 9-(4-hydroxy-3-hydroxymethylbutyl-1-yl)guanine
ADP + 9-(4-hydroxy-3-hydroxymethylbutyl-1-yl)guanine 5'-monophosphate
-
antiherpesvirus drug penciclovir, recombinant mitochondrial deoxyguanosine kinase, 50% of activity with deoxyguanosine
-
?
ATP + 9-beta-D-arabinofuranosylguanine
ADP + 9-beta-D-arabinofuranosylguanine 5'-monophosphate
ATP + 9-beta-D-arabinofuranosylguanine
ADP + 9-beta-D-arabinofuranosylguanine 5'-phosphate
-
-
-
?
ATP + 9-beta-D-arabinosylguanine
ADP + 9-beta-D-arabinosylguanine 5'-monophosphate
-
-
-
?
ATP + arabinosyl adenine
ADP + arabinosyl adenine 5'-monophosphate
-
recombinant mitochondrial deoxyguanosine kinase, very low activity
-
?
ATP + arabinosyl guanine
ADP + arabinosyl guanine 5'-monophosphate
-
recombinant mitochondrial deoxyguanosine kinase, better substrate than deoxyguanosine kinase
-
?
ATP + dideoxyinosine
ADP + dideoxyinosine 5'-monophosphate
-
recombinant mitochondrial deoxyguanosine kinase, very low activity
-
?
ATP + ganciclovir
ADP + ganciclovir phosphate
i.e. 9-(1,3-dihydroxy-2-propoxymethyl)-guanine, low activity
-
-
?
ATP + penciclovir
ADP + penciclovir 5'-phosphate
i.e. 9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-guanine, low activity
-
-
?
dUTP + deoxyguanosine
dUDP + dGMP
-
69% of activity with ATP at pH 6.0, 1.7fold higher activity than with ATP at pH 7.0
-
?
GTP + 2'-deoxyadenosine
GDP + 2'-deoxyadenosine 5'-phosphate
-
very low activity
-
-
?
GTP + 2'-deoxycytidine
GDP + 2'-deoxycytidine 5'-phosphate
-
very low activity
-
-
?
triphosphate + 2'-deoxyguanosine
diphosphate + 2'-deoxyguanosine 5'-phosphate
-
triphosphate is active with 2'deoxyguanosine, 50% of the activity with ATP
-
-
?
UTP + 2'-deoxyadenosine
UDP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
UTP + 9-beta-D-arabinofuranosylguanine
UDP + 9-beta-D-arabinofuranosylguanine 5'-phosphate
i.e. nelarabine, activation of the anticancer drug
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
-
key enzyme in mitochondrial DNA precursor synthesis
-
-
?
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
key enzyme in mitochondrial DNA precursor synthesis
-
-
?
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
important enzyme for the phosphorylation/activation of 2'-deoxyguanosine
-
-
ir
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
one of the two mitochondrial deoxynucleoside salvage pathway enzymes involved in precursor synthesis for mitochondrial DNA replication, DGUOK is responsible for the initial rate-limiting phosphorylation of the purine deoxynucleosides, mutations of the enzyme are associated with the hepato-specific and hepatocerebral forms of the mtDNA depletion syndrome
-
-
?
ATP + 2-chloro-2'-deoxyadenosine
ADP + 2-chloro-2'-deoxyadenosine monophosphate
-
-
-
?
ATP + 2-chloro-2'-deoxyadenosine
ADP + 2-chloro-2'-deoxyadenosine monophosphate
-
recombinant mitochondrial deoxyguanosine kinase
-
?
ATP + 2-chloro-2'-deoxyadenosine
ADP + 2-chloro-2'-deoxyadenosine monophosphate
recombinant mitochondrial deoxyguanosine kinase, 200% of activity with deoxyguanosine at 0.005 mM
-
?
ATP + 9-beta-D-arabinofuranosylguanine
ADP + 9-beta-D-arabinofuranosylguanine 5'-monophosphate
-
-
-
-
?
ATP + 9-beta-D-arabinofuranosylguanine
ADP + 9-beta-D-arabinofuranosylguanine 5'-monophosphate
-
guanosine analog with activity in patients with T-cell malignancies
-
?
ATP + deoxyadenosine
ADP + dAMP
barely measurable phosphorylation of deoxyadenosine
-
-
?
ATP + deoxyadenosine
ADP + dAMP
-
recombinant mitochondrial deoxyguanosine kinase
-
?
ATP + deoxyadenosine
ADP + dAMP
-
4.8%, 25.8% and 93.5% of activity with deoxyguanosine at 0.01 mM, 0.1 mM and 1 mM deoxyguanosine, respectively
-
?
ATP + deoxyadenosine
ADP + dAMP
recombinant mitochondrial deoxyguanosine kinase, very low activity
-
?
ATP + deoxycytidine
ADP + dCMP
-
recombinant deoxyguanosine kinase, 3% of activity with deoxyguanosine
-
-
?
ATP + deoxycytidine
ADP + dCMP
-
recombinant mitochondrial deoxyguanosine kinase
-
?
ATP + deoxyguanosine
ADP + dGMP
-
poor donor substrates are dATP or GTP
-
?
ATP + deoxyguanosine
ADP + dGMP
-
no activity with inosine and 9-beta-arabinofuranosyladenine
-
?
ATP + deoxyguanosine
ADP + dGMP
-
no activity with deoxythymidine, uridine and cytosine
-
?
ATP + deoxyguanosine
ADP + dGMP
-
ATP most efficient at pH 5.5, dTTP or UTP most efficient, i.e. more efficient than ATP, at pH 7.4
-
?
ATP + deoxyguanosine
ADP + dGMP
-
ATP can be replaced by dTTP, CTP, dCTP and UTP
-
?
ATP + deoxyguanosine
ADP + dGMP
-
highly specific for phospho group acceptor
-
?
ATP + deoxyguanosine
ADP + dGMP
-
enzyme of purine deoxynucleoside salvage pathway
-
?
ATP + deoxyguanosine
ADP + dGMP
-
-
-
-
?
ATP + deoxyguanosine
ADP + dGMP
-
recombinant mitochondrial deoxyguanosine kinase does not discriminate between beta-D-2'-deoxyguanosine and beta-L-2'-deoxyguanosine
-
?
ATP + deoxyguanosine
ADP + dGMP
-
ATP can be replaced by dTTP, CTP, dCTP and UTP
-
?
ATP + deoxyguanosine
ADP + dGMP
-
no activity with deoxythymidine, uridine and cytosine
-
?
ATP + deoxyguanosine
ADP + dGMP
-
ATP can be replaced by dTTP, CTP, dCTP and UTP
-
?
ATP + deoxyguanosine
ADP + dGMP
-
84%, 64%, 35% and 20% of activity with ATP with dTTP, CTP, dCTP and UTP, respectively
-
?
ATP + deoxyguanosine
ADP + dGMP
-
first reaction in reutilization of deoxyguanosine for dGTP biosynthesis
-
?
ATP + deoxyguanosine
ADP + dGMP
-
highly specific for phospho group acceptor
-
?
ATP + deoxyguanosine
ADP + dGMP
-
ATP twice as effective as CTP or GTP and 4 times as effective as UTP
-
?
ATP + deoxyinosine
ADP + dIMP
-
63% of activity with deoxyguanosine
-
?
ATP + deoxyinosine
ADP + dIMP
-
recombinant mitochondrial deoxyguanosine kinase
-
?
ATP + deoxyinosine
ADP + dIMP
-
recombinant mitochondrial deoxyguanosine kinase, may be the preferred substrate in vivo
-
?
ATP + deoxyinosine
ADP + dIMP
10% of activity with deoxyguanosine
-
?
ATP + dioxolane guanosine
ADP + dioxolane guanosine 5'-phosphate
-
low activity, step in anabolism of amdoxovir, i.e. (-)-beta-D-2,6-diaminopurine dioxolane, a prodrug of dioxolane guanosine
-
-
?
ATP + dioxolane guanosine
ADP + dioxolane guanosine 5'-phosphate
-
0.02% of the activity with 2'-deoxyguanosine
-
-
?
ATP + guanosine
ADP + GMP
-
recombinant deoxyguanosine kinase, 7% of activity with deoxyguanosine
-
?
CTP + deoxyguanosine
CDP + dGMP
-
62% of activity with ATP at pH 6.0, 1.8fold higher activity than with ATP at pH 7.0
-
?
dTTP + deoxyguanosine
dTDP + dGMP
-
83% of activity with ATP at pH 6.0, 2.8fold higher activity than with ATP at pH 7.0
-
?
UTP + 2'-deoxyguanosine
UDP + 2'-deoxyguanosine 5'-phosphate
-
preferred substrates
-
-
?
UTP + 2'-deoxyguanosine
UDP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
additional information
?
-
-
substrate specificity, the enzyme utilizes all naturally occurring ribo-and deoxyribonucleosides triphosphates, with the exception of dGTP, as phosphate donors, and shows poor activity with thymidine, inosine, adenosine, 2,3-dideoxyguanosine, 2,3-dideoxyinosine, 2,3-dideoxyadenosine, and hypoxanthine arabinoside as acceptor substrates
-
-
?
additional information
?
-
the enzyme has low specificity for guanosine
-
-
?
additional information
?
-
the enzyme has low specificity for guanosine
-
-
?
additional information
?
-
-
no activity with diphosphate as phosphate donor
-
-
?
additional information
?
-
de novo synthesis and salvage of ribonucleotides and deoxyribonucleotides, metabolism overview
-
-
?
additional information
?
-
-
enzyme defect due to genetic alterations leads to tissue-specific mitochondrial DNA depletion causing multi-systemic disease or devastating liver disease
-
-
?
additional information
?
-
-
th enzyme catalyzes the initial phosphorylation of purine deoxynucleosides, enzyme deficiency leads to severe mitochondrial DNA depletion diseases
-
-
?
additional information
?
-
the earliest nucleotide kinase in evolution, probably encoded by the so-called dCK/dGK/TK2-like gene, is the progenitor gene, several duplications of it are the reason for evolutionary occurring of nucleoside kinases with strict substrate specificities in other organism, phylogenetic tree, overview
-
-
?
additional information
?
-
anticancer drugs 2-chloro-2'-deoxyadenosine, i.e. cladribine, and 2-fluoro-9-beta-D-arabinofuranosyladenine, i.e. clofarabine, are poor substrates
-
-
?
additional information
?
-
-
no activity with several difluorophenyl nucleoside analogues, overview
-
-
?
additional information
?
-
substrate interactions, overview, enzyme shows relaxed enantioselectivity, accepting D- and L-enantiomers of beta-deoxyguanosine but with lower activity than alpha-L-deoxyguanosine, and beta-L-deoxyadenosine, enzyme accepts purine deoxynucleosides and analogues as substrates utilizing a triphosphate donor substrate
-
-
?
additional information
?
-
the enzyme is highly specific for purine substrates, Arg118 is responsible for the substrate specificity
-
-
?
additional information
?
-
-
the enzyme is highly specific for purine substrates, Arg118 is responsible for the substrate specificity
-
-
?
