2.7.1.113: deoxyguanosine kinase

This is an abbreviated version!
For detailed information about deoxyguanosine kinase, go to the full flat file.

Reaction

Synonyms

(dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, deoxyadenosine kinase/deoxyguanosine kinase, deoxyguanosine kinase, DG kinase, DGK, dGKase, DGUOK, kinase, deoxyguanosine (phosphorylating), NTP-deoxyguanosine 5'-phosphotransferase, nucleoside triphosphate: deoxyguanosine 5'-phosphotransferase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.113 deoxyguanosine kinase

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Results	in table
15	Activating Compound
771	AA Sequence
2	Application
1	CAS Registry Number
14	Cloned(Commentary)
33	Cofactor
2	Crystallization (Commentary)
334	Disease/ Diagnostics
2	Expression
9	General Information
9	General Stability
95	Inhibitors
5	kcat/KM [mM/s]
36	Ki Value [mM]
99	KM Value [mM]
32	Localization
47	Metals/Ions
13	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
59	Organism
5	Pathway
18	PDB ID
15	pH Optimum
5	pH Range
3	pH Stability
2	pI Value
42	Protein Variants
9	Purification (Commentary)
5	Reaction
1	Reaction Type
54	Reference
69	Source Tissue
19	Specific Activity [micromol/min/mg]
6	Storage Stability
175	Substrates and Products (Substrate)
8	Subunits
43	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
23	Turnover Number [1/s]

KI Value

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KI Value on EC 2.7.1.113 - deoxyguanosine kinase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.117

1-alpha-D-arabinofuranosylguanine

Bos taurus

-

pH 7.4, 37°C, competitive vs. deoxyguanosine, mitochondrial deoxyguanosine kinase

640551

0.43

8-aza-2'-deoxyguanosine

Bos taurus

-

pH 7.4, 37°C, competitive vs. deoxyguanosine, mitochondrial deoxyguanosine kinase

640551

1

ADP

Bos taurus

-

pH 7.4, 37°C, noncompetitive vs. deoxyguanosine, mitochondrial deoxyguanosine kinase

640554

0.028

dAMP

Homo sapiens

-

pH 7.6, 37°C, recombinant deoxyguanosine kinase

640562

0.041

dATP

Homo sapiens

-

pH 7.6, 37°C, recombinant deoxyguanosine kinase

640562

0.34

deoxyadenosine

Sus scrofa

-

pH 8.0, 37°C

640552

0.075

deoxyinosine

Bos taurus

-

pH 7.4, 37°C, competitive vs. deoxyguanosine, mitochondrial deoxyguanosine kinase

640551

0.00052 - 0.0087

dGDP

3 entries

0.004 - 0.25

dGMP

7 entries

0.00003 - 0.021

dGTP

8 entries

0.031 - 0.098

dIMP

3 entries

0.0001 - 0.0026

dITP

2 entries

0.21 - 0.73

dTDP

3 entries

0.003 - 0.063

UDP

2 entries

additional information

additional information

Bacillus subtilis

-

product inhibition of the enzyme, overview

640561

-

0.00052

dGDP

Bos taurus

-

pH 7.4, 37°C, vs. ATP, mitochondrial deoxyguanosine kinase

640554

0.0007

dGDP

Mus musculus

-

pH 5.2, 37°C, competitive vs. MgATP2-, at MgATP2- concentrations above 0.5 mM

640549

0.0087

dGDP

Bos taurus

-

pH 7.4, 37°C, vs. deoxyguanosine, mitochondrial deoxyguanosine kinase

640554

0.004

dGMP

Homo sapiens

-

pH 7.6, 37°C, recombinant deoxyguanosine kinase

640562

0.0058

dGMP

Bos taurus

-

pH 7.4, 37°C, vs. ATP mitochondrial deoxyguanosine kinase

640554

0.009

dGMP

Bos taurus

-

pH 7.4, 37°C, vs. dTTP, mitochondrial deoxyguanosine kinase

640554

0.076

dGMP

Sus scrofa

-

pH 8.0, 37°C

640552

0.1

dGMP

Bos taurus

-

pH 7.4, 37°C, vs. deoxyguanosine, mitochondrial deoxyguanosine kinase

640554

0.18

dGMP

Mus musculus

-

pH 5.2, 37°C, competitive vs. deoxyguanosine

640549

0.25

dGMP

Bos taurus

-

pH 7.4, 37°C, vs.ATP, mitochondrial deoxyguanosine kinase

640554

0.00003

dGTP

Bos taurus

-

pH 7.4, 37°C, vs. ATP, mitochondrial deoxyguanosine kinase

640554

0.00007

dGTP

Mus musculus

-

pH 5.2, 37°C, competitive vs. MgATP2-, at MgATP2- concentrations above 0.5 mM

640549

0.0004

dGTP

Homo sapiens

-

pH 7.6, 37°C, recombinant deoxyguanosine kinase

640562

0.00093

dGTP

Bos taurus

-

pH 7.4, 37°C, vs. deoxyguanosine, mitochondrial deoxyguanosine kinase

640554

0.0019

dGTP

Mus musculus

-

pH 5.2, 37°C, competitive vs. deoxyguanosine

640549

0.0019

dGTP

Lactobacillus acidophilus

-

pH 8.0, 20°C, vs. ATP

640565

0.00333

dGTP

Lactobacillus acidophilus

-

pH 8.0, 20°C, vs. deoxyguanosine

640565

0.021

dGTP

Sus scrofa

-

pH 8.0, 37°C

640552

0.031

dIMP

Bos taurus

-

pH 7.4, 37°C, vs. ATP, mitochondrial deoxyguanosine kinase

640554

0.078

dIMP

Homo sapiens

-

pH 7.6, 37°C, recombinant deoxyguanosine kinase

640562

0.098

dIMP

Bos taurus

-

pH 7.4, 37°C, vs. deoxyguanosine, mitochondrial deoxyguanosine kinase

640554

0.0001

dITP

Bos taurus

-

pH 7.4, 37°C, vs. ATP, mitochondrial deoxyguanosine kinase

640554

0.0026

dITP

Bos taurus

-

pH 7.4, 37°C, vs. deoxyguanosine, mitochondrial deoxyguanosine kinase

640554

0.21

dTDP

Bos taurus

-

pH 7.4, 37°C, vs. ATP, mitochondrial deoxyguanosine kinase

640554

0.39

dTDP

Bos taurus

-

pH 7.4, 37°C, vs. deoxyguanosine, mitochondrial deoxyguanosine kinase

640554

0.73

dTDP

Bos taurus

-

pH 7.4, 37°C, vs. dTTP, mitochondrial deoxyguanosine kinase

640554

0.003

UDP

Mus musculus

-

pH 5.2, 37°C, competitive vs. MgATP2-, at MgATP2- concentrations above 0.5 mM

640549

0.063

UDP

Bacillus subtilis

-

pH 8.5, 37°C, cosubstrate UTP

640561