2.7.1.113: deoxyguanosine kinase

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For detailed information about deoxyguanosine kinase, go to the full flat file.

Reaction

Synonyms

(dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, deoxyadenosine kinase/deoxyguanosine kinase, deoxyguanosine kinase, DG kinase, DGK, dGKase, DGUOK, kinase, deoxyguanosine (phosphorylating), NTP-deoxyguanosine 5'-phosphotransferase, nucleoside triphosphate: deoxyguanosine 5'-phosphotransferase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.113 deoxyguanosine kinase

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Results	in table
15	Activating Compound
771	AA Sequence
2	Application
1	CAS Registry Number
14	Cloned(Commentary)
33	Cofactor
2	Crystallization (Commentary)
334	Disease/ Diagnostics
2	Expression
9	General Information
9	General Stability
95	Inhibitors
5	kcat/KM [mM/s]
36	Ki Value [mM]
99	KM Value [mM]
32	Localization
47	Metals/Ions
13	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
59	Organism
5	Pathway
18	PDB ID
15	pH Optimum
5	pH Range
3	pH Stability
2	pI Value
42	Protein Variants
9	Purification (Commentary)
5	Reaction
1	Reaction Type
54	Reference
69	Source Tissue
19	Specific Activity [micromol/min/mg]
6	Storage Stability
175	Substrates and Products (Substrate)
8	Subunits
43	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
23	Turnover Number [1/s]

Expression

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Expression on EC 2.7.1.113 - deoxyguanosine kinase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

enzyme expression is downregulated by didanosine (2',3'-dideoxyinosine) to about 40%

Homo sapiens

-

737599

treatment with 3'-azido-2',3'-dideoxythymidine (zidovudine) treatment leads to downregulation of the mitochondrial enzyme in U2OS cells. Incubation with 1 mM tert-butylhydroperoxide results in 80% and 65% reductions in mitochondrial protein levels. Similarly, incubation with 2 mM diamide leads to about 50% decreases in enzyme expression

Homo sapiens

-

737461