2.3.1.256: N-terminal methionine Nalpha-acetyltransferase NatC
This is an abbreviated version!
For detailed information about N-terminal methionine Nalpha-acetyltransferase NatC, go to the full flat file.
Word Map on EC 2.3.1.256
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2.3.1.256
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acetyltransferases
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dsrnas
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viruslike
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nonfermentable
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co-translationally
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non-mendelian
- 2.3.1.256
- acetyltransferases
- dsrnas
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viruslike
-
nonfermentable
-
co-translationally
-
non-mendelian
Reaction
Synonyms
EC 2.3.1.88, EGAP, embryonic growth-associated protein, hNaa30, MAK10, MAK3, MAK31, Mak31p, Mak3p, N-alpha acetyltransferase 30, N-alpha-acetyltransferase 30, N-terminal acetyltransferase, N-terminal acetyltransferase complex C, N-terminal acetyltransferase Naa30, NAA30, NAA35, NAA38, Nalpha-acetyltransferase, Nalpha-terminal acetyltransferase complex C, NAT12, NatC, PAM21, protein methionine N-acetyltransferase, RimI, RimI acetyltransferase, Rv3420c, TcNaa30, TcNaa35, TcNatC
ECTree
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Substrates Products
Substrates Products on EC 2.3.1.256 - N-terminal methionine Nalpha-acetyltransferase NatC
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REACTION DIAGRAM
acetyl-CoA + an N-terminal-L-methionyl-L-histidyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-histidyl-[protein] + CoA
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-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA
acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[Arl8b protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[Arl8b protein] + CoA
high activity, the full sequence is MLALISRRWGRPVGRRRRPVRVYP
-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[L-A double-stranded RNA virus major coat protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[L-A double-stranded RNA virus major coat protein] + CoA
acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[mTOR protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[mTOR protein] + CoA
highest activity. The full sequence is MLGTGPARWGRPVGRRRRPVRVYP
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-
?
acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA
acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[RNP F protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[RNP F protein] + CoA
the full sequence is MLGTEGGRWGRPVGRRRRPVRVYP
-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[RNP H protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[RNP H protein] + CoA
high activity, the full sequence is MLGTEGGRWGRPVGRRRRPVRVYP
-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-lysyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-lysyl-[protein] + CoA
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-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-methionyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-methionyl-[protein] + CoA
-
-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA
acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA
acetyl-CoA + an N-terminal-L-methionyl-L-tyrosinyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosinyl-[protein] + CoA
acetyl-CoA + an N-terminal-L-methionyl-L-valyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-valyl-[protein] + CoA
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-
-
?
acetyl-CoA + N-terminal-L-methionyl-L-alanyl-[PLD]
N-terminal-Nalpha-acetyl-L-methionyl-L-alanyl-[PLD] + CoA
a NatF-type substrate
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-
?
acetyl-CoA + N-terminal-L-methionyl-L-isoleucyl-[Lrg1 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[Lrg1 protein] + CoA
acetyl-CoA + N-terminal-L-methionyl-L-isoleucyl-[Sly41 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[Sly41 protein] + CoA
acetyl-CoA + N-terminal-L-methionyl-L-isoleucyl-[Ymr31 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[Ymr31 protein] + CoA
acetyl-CoA + N-terminal-L-methionyl-L-leucyl-glycyl-L-proline
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-glycyl-L-proline + CoA
acetyl-CoA + N-terminal-L-methionyl-L-leucyl-[Bem1 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[Bem11 protein] + CoA
acetyl-CoA + N-terminal-L-methionyl-L-leucyl-[Glr1 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[Glr1 protein] + CoA
-
-
-
-
?
acetyl-CoA + N-terminal-L-methionyl-L-leucyl-[GPE]
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[GPE] + CoA
a NatE-type substrate
-
-
?
acetyl-CoA + N-terminal-L-methionyl-L-leucyl-[GTG]
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[GTG] + CoA
a NatC-type substrate
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-
?
acetyl-CoA + N-terminal-L-methionyl-L-leucyl-[Pda1 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[Pda1 protein] + CoA
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-
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?
acetyl-CoA + N-terminal-L-methionyl-L-leucyl-[RYFRR]
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[RYFRR] + CoA
DP11 peptide (MARYFRR) is a substrate of NatC, a synthetic peptide
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ir
acetyl-CoA + N-terminal-L-methionyl-L-leucyl-[Trm1-II protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[Trm1-II protein] + CoA
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-
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?
acetyl-CoA + N-terminal-L-methionyl-L-phenylalanyl-[Arl3 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[Arl3 protein] + CoA
acetyl-CoA + N-terminal-L-methionyl-L-phenylalanyl-[Rfc2 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[Rfc2 protein] + CoA
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-
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?
acetyl-CoA + N-terminal-L-methionyl-L-phenylalanyl-[Rrn11 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[Rrn11 protein] + CoA
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-
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?
acetyl-CoA + N-terminal-L-methionyl-L-phenylalanyl-[Sec18 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[Sec18 protein] + CoA
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?
acetyl-CoA + N-terminal-L-methionyl-L-phenylalanyl-[Tma20 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[Tma20 protein] + CoA
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?
acetyl-CoA + N-terminal-L-methionyl-L-tyrosinyl-[Nup157 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosinyl-[Nup157 protein] + CoA
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-
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?
acetyl-CoA + N-terminal-L-methionyl-L-tyrosinyl-[Pxl1 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosinyl-[Pxl1 protein] + CoA
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-
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?
acetyl-CoA + N-terminal-L-methionyl-L-tyrosinyl-[Tgl1 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosinyl-[Tgl1 protein] + CoA
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-
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?
an N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA
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-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA
-
-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA
-
-
-
-
?
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[L-A double-stranded RNA virus major coat protein] + CoA
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-
-
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?
acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[L-A double-stranded RNA virus major coat protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[L-A double-stranded RNA virus major coat protein] + CoA
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-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[L-A double-stranded RNA virus major coat protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[L-A double-stranded RNA virus major coat protein] + CoA
-
-
-
?
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA
-
-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA
-
-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA
-
-
-
-
?
an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA
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-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA
-
-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA
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-
-
-
?
an N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA
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-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA
-
-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA
-
-
-
-
?
an N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosinyl-[protein] + CoA
-
-
-
?
acetyl-CoA + an N-terminal-L-methionyl-L-tyrosinyl-[protein]
an N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosinyl-[protein] + CoA
-
-
-
?
N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[Lrg1 protein] + CoA
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-
-
-
?
acetyl-CoA + N-terminal-L-methionyl-L-isoleucyl-[Lrg1 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[Lrg1 protein] + CoA
-
-
-
-
?
N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[Sly41 protein] + CoA
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-
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?
acetyl-CoA + N-terminal-L-methionyl-L-isoleucyl-[Sly41 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[Sly41 protein] + CoA
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-
-
-
?
N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[Ymr31 protein] + CoA
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-
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?
acetyl-CoA + N-terminal-L-methionyl-L-isoleucyl-[Ymr31 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[Ymr31 protein] + CoA
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-
-
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?
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-glycyl-L-proline + CoA
Q4CRN8; Q4DLD9; Q4D159, Q4DGZ6; Q4DJ45; Q4D159
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ir
acetyl-CoA + N-terminal-L-methionyl-L-leucyl-glycyl-L-proline
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-glycyl-L-proline + CoA
Q4CRN8; Q4DLD9; Q4D159, Q4DGZ6; Q4DJ45; Q4D159
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ir
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[Bem11 protein] + CoA
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?
acetyl-CoA + N-terminal-L-methionyl-L-leucyl-[Bem1 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[Bem11 protein] + CoA
-
-
-
-
?
N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[Arl3 protein] + CoA
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-
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?
acetyl-CoA + N-terminal-L-methionyl-L-phenylalanyl-[Arl3 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[Arl3 protein] + CoA
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-
-
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?
acetyl-CoA + N-terminal-L-methionyl-L-phenylalanyl-[Arl3 protein]
N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[Arl3 protein] + CoA
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?
?
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almost no activity with nuclear factor kappaB p65 (MDELFPLRWGRPVGRRRRPVRVYP), kinesin KIF4A (MKEEVKGRWGRPVGRRRRPVRVYP), and high-mobility group protein A1 (SESSSKSRWGRPVGRRRRPVRVYP)
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?
additional information
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full-length Naa30 acetylates a classical NatC substrate peptide in vitro, whereas no significant NAT activity is detected for Naa3028. Neither full-length Naa30 nor Naa30288 display any lysine acetyltransferase activity, and neither Naa30 isoforms have KAT activity towards histones. The SESSS, EEEIA and MDELF peptides are negative controls and represent NatA, Naa10 and NatB substrates, respectively. Poor activity with SGRGK peptide, which contains the natural 28-mer N-terminal sequence of histone H4, and represents a NatD-type substrate
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additional information
?
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full-length Naa30 acetylates a classical NatC substrate peptide in vitro, whereas no significant NAT activity is detected for Naa3028. Neither full-length Naa30 nor Naa30288 display any lysine acetyltransferase activity, and neither Naa30 isoforms have KAT activity towards histones. The SESSS, EEEIA and MDELF peptides are negative controls and represent NatA, Naa10 and NatB substrates, respectively. Poor activity with SGRGK peptide, which contains the natural 28-mer N-terminal sequence of histone H4, and represents a NatD-type substrate
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additional information
?
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analysis of substrate preference of RimIMtb: substrate peptide DPC (NatA substrate) is custom synthesized with single residue modifications at its N-terminus to represent substrate specificities of NatE (DP9), NatB (DP10), NatC (DP11), and substrate Leu (DP8) and tested, all the peptides are modified by RimIMtb, substrates and sequences, detailed overview. The NatB substrate peptide MERYFRR (DP10) is a poor substrate for RimI. RimIMtb does acetylate peptides representing N-terminus of GroES, GroEL1, and TsaD proteins, in vitro. Significant specific activity of RimIMtb is observed gainst peptide representing N-terminus of GroES. RimIMtb acetylates DP11 (NatC substrate) about 1.7fold better than DPC (NatA substrate). RimIMtb acetylates N-terminus of ribosomal proteins and of neighboring non-ribosomal proteins
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additional information
?
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Q4CRN8; Q4DLD9; Q4D159
analysis of in vitro acetyltransferase activity of GST-tagged TcNaa30: no activity with peptides STPD, EEEIA, MDEL, and MLGP
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additional information
?
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Q4DGZ6; Q4DJ45; Q4D159
analysis of in vitro acetyltransferase activity of GST-tagged TcNaa30: no activity with peptides STPD, EEEIA, MDEL, and MLGP
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-
-
additional information
?
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Q4CRN8; Q4DLD9; Q4D159
analysis of in vitro acetyltransferase activity of GST-tagged TcNaa30: no activity with peptides STPD, EEEIA, MDEL, and MLGP
-
-
-
additional information
?
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Q4DGZ6; Q4DJ45; Q4D159
analysis of in vitro acetyltransferase activity of GST-tagged TcNaa30: no activity with peptides STPD, EEEIA, MDEL, and MLGP
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