2.3.1.256: N-terminal methionine Nalpha-acetyltransferase NatC
This is an abbreviated version!
For detailed information about N-terminal methionine Nalpha-acetyltransferase NatC, go to the full flat file.
Word Map on EC 2.3.1.256
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2.3.1.256
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acetyltransferases
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dsrnas
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viruslike
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nonfermentable
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co-translationally
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non-mendelian
- 2.3.1.256
- acetyltransferases
- dsrnas
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viruslike
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nonfermentable
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co-translationally
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non-mendelian
Reaction
Synonyms
EC 2.3.1.88, EGAP, embryonic growth-associated protein, hNaa30, MAK10, MAK3, MAK31, Mak31p, Mak3p, N-alpha acetyltransferase 30, N-alpha-acetyltransferase 30, N-terminal acetyltransferase, N-terminal acetyltransferase complex C, N-terminal acetyltransferase Naa30, NAA30, NAA35, NAA38, Nalpha-acetyltransferase, Nalpha-terminal acetyltransferase complex C, NAT12, NatC, PAM21, protein methionine N-acetyltransferase, RimI, RimI acetyltransferase, Rv3420c, TcNaa30, TcNaa35, TcNatC
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Engineering
Engineering on EC 2.3.1.256 - N-terminal methionine Nalpha-acetyltransferase NatC
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additional information
identification of a splice variant of human NAA30, which encodes a truncated protein named Naa30288. DNA sequencing reveals that the 900 bp product derived from alternative splicing results in a 222 bp deletion from the 3' end of exon 1 (c.550_771del). The truncated splice variant (867 bp) is otherwise identical to NAA30. Splicing NAA30_v2 translates into a truncated isoform (p.Val184_Leu257del) consisting of 288 amino acids (Naa30288). The splice variant is abundantly present in thyroid cancer tissues and in several different human cancer cell lines. Naa30288 localizes predominantly to the nucleus, as opposed to annotated Naa30 which has a cytoplasmic localization. Naa30288 is missing elements of the GNAT fold. Full-length Naa30 acetylates the classical NatC substrate peptide MLGTG in vitro, whereas no significant NAT activity is detected for Naa3028. Naa30288 appears to be enzymatically inactive. Overexpression of full-length Naa30362 increases cell viability via inhibition of apoptosis. In contrast, Naa30288 does not exert an anti-apoptotic effect
additional information
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identification of a splice variant of human NAA30, which encodes a truncated protein named Naa30288. DNA sequencing reveals that the 900 bp product derived from alternative splicing results in a 222 bp deletion from the 3' end of exon 1 (c.550_771del). The truncated splice variant (867 bp) is otherwise identical to NAA30. Splicing NAA30_v2 translates into a truncated isoform (p.Val184_Leu257del) consisting of 288 amino acids (Naa30288). The splice variant is abundantly present in thyroid cancer tissues and in several different human cancer cell lines. Naa30288 localizes predominantly to the nucleus, as opposed to annotated Naa30 which has a cytoplasmic localization. Naa30288 is missing elements of the GNAT fold. Full-length Naa30 acetylates the classical NatC substrate peptide MLGTG in vitro, whereas no significant NAT activity is detected for Naa3028. Naa30288 appears to be enzymatically inactive. Overexpression of full-length Naa30362 increases cell viability via inhibition of apoptosis. In contrast, Naa30288 does not exert an anti-apoptotic effect
additional information
siRNA-mediated knockdown of hNAA30 gene expression in HeLa and CAL-62 cells, phenotypes, detailed overview
additional information
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siRNA-mediated knockdown of hNAA30 gene expression in HeLa and CAL-62 cells, phenotypes, detailed overview