1.1.1.88: hydroxymethylglutaryl-CoA reductase
This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase, go to the full flat file.
Word Map on EC 1.1.1.88
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1.1.1.88
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cholesterol
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statin
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lipoprotein
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simvastatin
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sterol
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low-density
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coronary
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cardiovascular
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lovastatin
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hypercholesterolemia
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pravastatin
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atorvastatin
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lipid-lowering
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cholesterol-lowering
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3-hydroxy-3-methylglutaryl-coa
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cerivastatin
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mevinolin
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alpha-hydroxylase
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statin-induced
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compactin
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mevalonolactone
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cholestyramine
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mevalonii
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lipoprotein-deficient
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medicine
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25-hydroxycholesterol
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fibric
- 1.1.1.88
- cholesterol
- statin
- lipoprotein
- simvastatin
- sterol
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low-density
- coronary
- cardiovascular
- lovastatin
- hypercholesterolemia
- pravastatin
- atorvastatin
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lipid-lowering
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cholesterol-lowering
- 3-hydroxy-3-methylglutaryl-coa
- cerivastatin
- mevinolin
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alpha-hydroxylase
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statin-induced
- compactin
- mevalonolactone
- cholestyramine
- mevalonii
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lipoprotein-deficient
- medicine
- 25-hydroxycholesterol
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fibric
Reaction
Synonyms
3-hydroxy-3-methylglutaryl CoA reductase 1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, HMG-CoA reductase, HMGCoAR, HMGR, hydroxymethylglutaryl coenzyme A reductase, Mt HMGR1, mvaA, NADH-dependent HMG-CoA reductase, NADH-HMGR
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase
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REACTION DIAGRAM
(R)-mevalonate + CoA + NADP+
3-hydroxy-3-methylglutaryl-CoA + NADPH + H+
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r
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
(R)-mevalonate + CoA + 2 NADP+
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extremely low activity with NADPH
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?
DL-mevaldate + CoA + NAD+
3-hydroxy-3-methylglutaryl-CoA NADH + H+
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r
DL-mevaldate + CoA + NAD+
4-hydroxy-3-methylglutaryl-CoA NADH + H+
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r
DL-mevaldate + CoA + NAD+
5-hydroxy-3-methylglutaryl-CoA NADH + H+
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r
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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r
(R)-mevalonate + CoA + 2 NAD+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
NAD(H) is the preferred cofactor
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r
(R)-mevalonate + CoA + 2 NAD+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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?
(R)-mevalonate + CoA + 2 NAD+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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?
(R)-mevalonate + CoA + 2 NAD+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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?
(R)-mevalonate + CoA + 2 NAD+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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?
(R)-mevalonate + CoA + 2 NAD+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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?
(R)-mevalonate + CoA + 2 NAD+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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r
(R)-mevalonate + CoA + 2 NAD+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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with mevalonate as sole source of carbon enzyme acts as a biodegradative enzyme
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?
(R)-mevalonate + CoA + 2 NAD+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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with mevalonate as sole source of carbon enzyme acts as a biodegradative enzyme
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r
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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r
(R)-mevalonate + CoA + 2 NAD+
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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?
(R)-mevalonate + CoA + 2 NAD+
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
Burkholderia cenocepacia 32315
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?
(R)-mevalonate + CoA + 2 NAD+
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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r
(R)-mevalonate + CoA + 2 NAD+
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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r
(R)-mevalonate + NAD+ + CoA
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mevalonate is required for cholesterol and isoprenoid synthesis
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?
(S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+
(R)-mevalonate + NAD+ + CoA
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?
(S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+
(R)-mevalonate + NAD+ + CoA
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mevalonate is first commited intermediate in polyisoprenoid synthesis
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mevalonate + CoA + NAD+
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3-hydroxy-3-methyl-glutaryl-CoA + NADH + H+
mevalonate + CoA + NAD+
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mevalonate pathway
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3-hydroxy-3-methyl-glutaryl-CoA + NADH + H+
mevalonate + CoA + NAD+
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(R)-mevalonate + CoA + 2 NAD+
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?
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
(R)-mevalonate + CoA + 2 NAD+
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the enzyme is highly specific for NADH
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mevalonate + CoA + NAD+
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?
3-hydroxy-3-methylglutaryl-CoA + NADH + H+
mevalonate + CoA + NAD+
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r
3-hydroxy-3-methylglutaryl-CoA + NADPH + H+
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r
DL-mevalonate + CoA + NADP+
3-hydroxy-3-methylglutaryl-CoA + NADPH + H+
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r
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the substrates of the reductive reaction, HMG-CoA and NADH, both demonstrate sigmoidal behavior typical of positive cooperativity
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?
additional information
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The enzyme can play a role in indole alkaloid biosynthesis and a possible cosuppression of both the endogenous and foreign enzyme genes in clone 236
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additional information
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oxidative acylation of mevalonate: the carboxy-, 3-methyl-, and 3-hydroxy groups are essential for substrate binding to the enzyme
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additional information
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oxidative acylation of mevalonate: the carboxy-, 3-methyl-, and 3-hydroxy groups are essential for substrate binding to the enzyme
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additional information
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oxidative acylation of mevalonate: the carboxy-, 3-methyl-, and 3-hydroxy groups are essential for substrate binding to the enzyme
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additional information
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oxidative acylation of mevalonate: the carboxy-, 3-methyl-, and 3-hydroxy groups are essential for substrate binding to the enzyme
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additional information
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The biosynthetic pathway leading to plant cytosolic isoprenoids begins with the 3-hydroxy-3-methyl-glutaryl CoA reductase-mediated production of mevalonate
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