Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-mevalonate + CoA + 2 NAD+ | Delftia acidovorans | - |
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | - |
r | |
(R)-mevalonate + CoA + 2 NAD+ | Pseudomonas mevalonii | - |
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | - |
r | |
(R)-mevalonate + CoA + 2 NAD+ | Bordetella petrii | - |
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bordetella petrii | - |
- |
- |
Delftia acidovorans | - |
- |
- |
Pseudomonas mevalonii | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.7 | - |
reverse reaction, pH 7.9, 30°C | Pseudomonas mevalonii |
2.73 | - |
forward reaction, pH 7.9, 30°C | Pseudomonas mevalonii |
4.87 | - |
reverse reaction, pH 7.9, 30°C | Delftia acidovorans |
11.94 | - |
forward reaction, pH 7.9, 30°C | Delftia acidovorans |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-mevalonate + CoA + 2 NAD+ | - |
Delftia acidovorans | 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | - |
r | |
(R)-mevalonate + CoA + 2 NAD+ | - |
Pseudomonas mevalonii | 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | - |
r | |
(R)-mevalonate + CoA + 2 NAD+ | - |
Bordetella petrii | 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
HMG-CoA reductase | - |
Delftia acidovorans |
HMG-CoA reductase | - |
Pseudomonas mevalonii |
HMG-CoA reductase | - |
Bordetella petrii |
NADH-dependent HMG-CoA reductase | - |
Delftia acidovorans |
NADH-dependent HMG-CoA reductase | - |
Pseudomonas mevalonii |
NADH-dependent HMG-CoA reductase | - |
Bordetella petrii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at, both reaction directions | Delftia acidovorans |
30 | - |
assay at, both reaction directions | Pseudomonas mevalonii |
30 | - |
assay at, both reaction directions | Bordetella petrii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.9 | - |
assay at, both reaction directions | Delftia acidovorans |
7.9 | - |
assay at, both reaction directions | Pseudomonas mevalonii |
7.9 | - |
assay at, both reaction directions | Bordetella petrii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | sequence comparisons of several species with class II (NAD(H)) and class I (NADP(H)) HMG-CoA reductases for analysis of cofactor binding, overview | Delftia acidovorans | |
additional information | sequence comparisons of several species with class II (NAD(H)) and class I (NADP(H)) HMG-CoA reductases for analysis of cofactor binding, overview | Bordetella petrii | |
additional information | sequence comparisons of several species with class II (NAD(H)) and class I (NADP(H)) HMG-CoA reductases for analysis of cofactor binding, specificity-determining residue of HMGR from Pseudomonas mevalonii is D646, overview | Pseudomonas mevalonii | |
NAD+ | - |
Delftia acidovorans | |
NAD+ | - |
Pseudomonas mevalonii | |
NAD+ | - |
Bordetella petrii | |
NADH | - |
Delftia acidovorans | |
NADH | - |
Pseudomonas mevalonii | |
NADH | - |
Bordetella petrii |
General Information | Comment | Organism |
---|---|---|
additional information | sequence comparisons of several species with class II and class I HMG-CoA reductases for analysis of cofactor binding, overview | Delftia acidovorans |
additional information | sequence comparisons of several species with class II and class I HMG-CoA reductases for analysis of cofactor binding, overview | Pseudomonas mevalonii |
additional information | sequence comparisons of several species with class II and class I HMG-CoA reductases for analysis of cofactor binding, overview | Bordetella petrii |