Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.88 extracted from

  • Rogers, K.S.; Rodwell, V.W.; Geiger, P.
    Active form of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase (1997), Biochem. Mol. Med., 61, 114-120.
    View publication on PubMed

Application

Application Comment Organism
medicine target enzyme for chemotherapy of hypercholesterolemias Pseudomonas mevalonii

Crystallization (Commentary)

Crystallization (Comment) Organism
wild-type and mutants, H381A, H381N, H381K, H381Q, 3 A resolution Pseudomonas mevalonii

Protein Variants

Protein Variants Comment Organism
H381K
-
Pseudomonas mevalonii
H381N
-
Pseudomonas mevalonii
H381Q
-
Pseudomonas mevalonii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45540
-
amino acid composition Pseudomonas mevalonii
270100
-
sedimentation equilibrium centrifugation Pseudomonas mevalonii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ Pseudomonas mevalonii
-
(R)-mevalonate + NAD+ + CoA
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas mevalonii
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ reaction mechanism purposal Pseudomonas mevalonii

Storage Stability

Storage Stability Organism
-180°C, 400 mM KCl, 24 months Pseudomonas mevalonii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-mevalonate + CoA + 2 NAD+
-
Pseudomonas mevalonii (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
-
?
(S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+
-
Pseudomonas mevalonii (R)-mevalonate + NAD+ + CoA
-
?

Subunits

Subunits Comment Organism
hexamer 3alpha2, XSA Pseudomonas mevalonii

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Pseudomonas mevalonii
NADH reverse reaction Pseudomonas mevalonii