Application | Comment | Organism |
---|---|---|
medicine | target enzyme for chemotherapy of hypercholesterolemias | Pseudomonas mevalonii |
Crystallization (Comment) | Organism |
---|---|
wild-type and mutants, H381A, H381N, H381K, H381Q, 3 A resolution | Pseudomonas mevalonii |
Protein Variants | Comment | Organism |
---|---|---|
H381K | - |
Pseudomonas mevalonii |
H381N | - |
Pseudomonas mevalonii |
H381Q | - |
Pseudomonas mevalonii |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45540 | - |
amino acid composition | Pseudomonas mevalonii |
270100 | - |
sedimentation equilibrium centrifugation | Pseudomonas mevalonii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ | Pseudomonas mevalonii | - |
(R)-mevalonate + NAD+ + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas mevalonii | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | reaction mechanism purposal | Pseudomonas mevalonii |
Storage Stability | Organism |
---|---|
-180°C, 400 mM KCl, 24 months | Pseudomonas mevalonii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-mevalonate + CoA + 2 NAD+ | - |
Pseudomonas mevalonii | (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | - |
? | |
(S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ | - |
Pseudomonas mevalonii | (R)-mevalonate + NAD+ + CoA | - |
? |
Subunits | Comment | Organism |
---|---|---|
hexamer | 3alpha2, XSA | Pseudomonas mevalonii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Pseudomonas mevalonii | |
NADH | reverse reaction | Pseudomonas mevalonii |