Sequence of CATL1_MOUSE
EC Number:3.4.22.15
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
Other sequences found for EC No. 3.4.22.15
General information:
Sequence
0 MNLLLLLAVL CLGTALATPK FDQTFSAEWH QWKSTHRRLY GTNEEEWRRA IWEKNMRMIQ
60 LHNGEYSNGQ HGFSMEMNAF GDMTNEEFRQ VVNGYRHQKH KKGRLFQEPL MLKIPKSVDW
120 REKGCVTPVK NQGQCGSCWA FSASGCLEGQ MFLKTGKLIS LSEQNLVDCS HAQGNQGCNG
180 GLMDFAFQYI KENGGLDSEE SYPYEAKDGS CKYRAEFAVA NDTGFVDIPQ QEKALMKAVA
240 TVGPISVAMD ASHPSLQFYS SGIYYEPNCS SKNLDHGVLL VGYGYEGTDS NKNKYWLVKN
300 SWGSEWGMEG YIKIAKDRDN HCGLATAASY PVVN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
398413
Troen B.R.,Gal S.,Gottesman M.M.
Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin.
Biochem. J.
246
731-735
1987
398414
Joseph L.J.,Chang L.C.,Stamenkovich D.,Sukhatme V.P.
Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.
J. Clin. Invest.
81
1621-1629
1988
398415
Portnoy D.A.,Erickson A.H.,Kochan J.,Ravetch J.V.,Unkeless J.C.
Cloning and characterization of a mouse cysteine proteinase.
J. Biol. Chem.
261
14697-14703
1986
398416
Stearns N.A.,Dong J.,Pan J.X.,Brenner D.A.,Sahagian G.G.
Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels.
Arch. Biochem. Biophys.
283
447-457
1990
398417
Baer G.S.,Ebert D.H.,Chung C.J.,Erickson A.H.,Dermody T.S.
Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.
J. Virol.
73
9532-9543
1999
398418
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
398419
Jean D.,Hermann J.,Rodrigues-Lima F.,Barel M.,Balbo M.,Frade R.
Identification on melanoma cells of p39, a cysteine proteinase that cleaves C3, the third component of complement: amino-acid-sequence identities with procathepsin L.
Biochem. J.
312
961-969
1995
398420
Denhardt D.T.,Hamilton R.T.,Parfett C.L.J.,Edwards D.R.,Pierre R.S.,Waterhouse P.,Nilson-Hamilton M.
Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.
Cancer Res.
46
4590-4593
1986
398421
Nakagawa T.,Roth W.,Wong P.,Nelson A.,Farr A.,Deussing J.,Villadangos J.A.,Ploegh H.,Peters C.,Rudensky A.Y.
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.
Science
280
450-453
1998
398422
Felbor U.,Dreier L.,Bryant R.A.,Ploegh H.L.,Olsen B.R.,Mothes W.
Secreted cathepsin L generates endostatin from collagen XVIII.
EMBO J.
19
1187-1194
2000
398423
Lennon-Dumenil A.M.,Roberts R.A.,Valentijn K.,Driessen C.,Overkleeft H.S.,Erickson A.,Peters P.J.,Bikoff E.,Ploegh H.L.,Wolf Bryant P.
The p41 isoform of invariant chain is a chaperone for cathepsin L.
EMBO J.
20
4055-4064
2001
398424
Benavides F.,Starost M.F.,Flores M.,Gimenez-Conti I.B.,Guenet J.L.,Conti C.J.
Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation.
Am. J. Pathol.
161
693-703
2002
398425
Honey K.,Nakagawa T.,Peters C.,Rudensky A.
Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands.
J. Exp. Med.
195
1349-1358
2002
398426
Fiebiger E.,Maehr R.,Villadangos J.,Weber E.,Erickson A.,Bikoff E.,Ploegh H.L.,Lennon-Dumenil A.M.
Invariant chain controls the activity of extracellular cathepsin L.
J. Exp. Med.
196
1263-1269
2002
398427
Stypmann J.,Glaeser K.,Roth W.,Tobin D.J.,Petermann I.,Matthias R.,Moennig G.,Haverkamp W.,Breithardt G.,Schmahl W.,Peters C.,Reinheckel T.
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.
Proc. Natl. Acad. Sci. U.S.A.
99
6234-6239
2002
398428
Friedrichs B.,Tepel C.,Reinheckel T.,Deussing J.,von Figura K.,Herzog V.,Peters C.,Saftig P.,Brix K.
Thyroid functions of mouse cathepsins B, K, and L.
J. Clin. Invest.
111
1733-1745
2003
398429
Yasothornsrikul S.,Greenbaum D.,Medzihradszky K.F.,Toneff T.,Bundey R.,Miller R.,Schilling B.,Petermann I.,Dehnert J.,Logvinova A.,Goldsmith P.,Neveu J.M.,Lane W.S.,Gibson B.,Reinheckel T.,Peters C.,Bogyo M.,Hook V.
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.
Proc. Natl. Acad. Sci. U.S.A.
100
9590-9595
2003
398430
Goulet B.,Baruch A.,Moon N.S.,Poirier M.,Sansregret L.L.,Erickson A.,Bogyo M.,Nepveu A.
A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.
Mol. Cell
14
207-219
2004
398431
Uematsu R.,Furukawa J.,Nakagawa H.,Shinohara Y.,Deguchi K.,Monde K.,Nishimura S.
High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis.
Mol. Cell. Proteomics
4
1977-1989
2005
398432
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
