EC Number   |
Protein Variants |
Reference |
|---|
   3.4.22.15 | A205L |
mutant shows an effective cathepsin K-like preference for Leu and Pro |
682739 |
| 3.4.22.15 | C143A |
site-directed mutagenesis |
753596 |
| 3.4.22.15 | C25A |
inactive |
718157 |
| 3.4.22.15 | C25S |
mutant constructed to confer silica condensing activity to cathepsin L. Mutation does not display significant condensing activity |
697291 |
| 3.4.22.15 | C25S |
site-directed mutagenesis, almost inactive mutant that still performs autocatalytic cleavage |
753565 |
| 3.4.22.15 | C25S/S24A/W26Y |
mutant constructed to confer silica condensing activity to cathepsin L. Mutant displays significant condensing activity |
697291 |
| 3.4.22.15 | C25S/S24A/W26Y/M161L/D162N/G164A/V165M |
mutant constructed to confer silica condensing activity to cathepsin L. Mutant displays significant condensing activity, but less than mutant C25S/S24A/W26Y |
697291 |
| 3.4.22.15 | G139R |
2fold decrease in binding affinity to the inhibitory fragment p41 of major histocompatibility complex class II-associated invariant chain |
698753 |
| 3.4.22.15 | G139R |
KI-value increased compared to wild-type |
698753 |
| 3.4.22.15 | L67Y/A205L |
mutation induces a switch of the enzymatic specificity toward small selective inhibitors and peptidyl substrates |
682739 |
