EC Number   |
Protein Variants |
Reference |
|---|
    2.4.2.4 | D203A |
site-directed mutagenesis, the mutant enzyme shows 50fold reduced catalytic efficiency compared to the wild-type enzyme, the mutant also shows pronounced resistance to the inhibitory effect of 5'-O-tritylinosine, and it keeps full sensitivity to the competitive inhibitors 6-aminothymine and 6-amino-5-bromouracil |
702162 |
| 2.4.2.4 | D203A |
site-directed mutagenesis, the mutant shows 60% reduced phosphorolytic activity compared to the wild-type enzyme. The mutant is inhibited by 6-aminothymine 6-amino-5-bromouracil, like the wild-type enzyme, but not by 5'-O-tritylinosine, in contrast to the wild-type enzyme |
705495 |
| 2.4.2.4 | H116F |
site-directed mutagenesis, inactive mutant |
702064 |
| 2.4.2.4 | H116K |
site-directed mutagenesis, inactive mutant |
702064 |
| 2.4.2.4 | I214A |
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme |
702064 |
| 2.4.2.4 | K115A |
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme |
702064 |
| 2.4.2.4 | K115E |
inactive mutant |
705495 |
| 2.4.2.4 | K115E |
loss of enzymic activity. Expression of mutant in rat vascular smooth muscle cell does not have significant effect on cell proliferation |
721729 |
| 2.4.2.4 | K115E |
no enzyme activity after transfection in COS-7 cells |
638464 |
| 2.4.2.4 | K115E |
site-directed mutagenesis, inactive mutant |
702064 |
