EC Number   |
Protein Variants |
Reference |
|---|
   1.6.2.4 | A115V |
Vmax/Km for cytochrome c is 63% of wild-type value, Vmax/Km for NADPH is 41% of wild-type value |
686913 |
| 1.6.2.4 | A264C |
no notable decreases in expression of the respective haem domains or flavocytochromes. For A264C haem domain, fatty-acid-induced perturbation of the spinstate equilibrium is observed in some cases, but the extent of high-spin conversion is substantially less than observed for wild-type with arachidonate |
690838 |
| 1.6.2.4 | A264M |
higher dodecanoate affinity than wild-type BM3. For the A264M mutant, a more substantial fatty-acid-induced high-spin conversion of haem iron is observed than for A264C, albeit slightly less than for wild-type with the same fatty acids. |
690838 |
| 1.6.2.4 | A264Q |
no notable decreases in expression of the respective haem domains or flavocytochromes |
690838 |
| 1.6.2.4 | A287P |
preferential inhibition of CYP17A1 over CYP21A2 |
688993 |
| 1.6.2.4 | A287P |
the POR mutant is associated with 75-80% of normal heme oxygenase-1 activity |
711112 |
| 1.6.2.4 | A287P |
Vmax/Km for cytochrome c is 9% of wild-type value, Vmax/Km for NADPH is 16% of wild-type value |
686913 |
| 1.6.2.4 | A457H |
the POR mutant is associated with total loss of heme oxygenase-1 activity |
711112 |
| 1.6.2.4 | A462T |
vmax/Km for ferricytochrome c is 85% of the wild-type value. Vmax/Km for NADPH is 69% of the wild-type value |
689794 |
| 1.6.2.4 | A485T |
vmax/Km for ferricytochrome c is 36% of the wild-type value. Vmax/Km for NADPH is 51% of the wild-type value |
689794 |
