EC Number   |
Protein Variants |
Reference |
|---|
    1.13.11.52 | A264G |
site-directed mutagenesis, mutation of a loop residues that connects the hIDO domains |
742005 |
| 1.13.11.52 | A4T |
variant observed in Homo sapiens |
700604 |
| 1.13.11.52 | C129A |
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme |
742442 |
| 1.13.11.52 | D274A |
mutant without enzyme activity, may be distal ligand or essential in maintaining the conformation of the heme pocket |
659233 |
| 1.13.11.52 | F185A |
mutation eliminates activity of the enzyme |
765149 |
| 1.13.11.52 | F226A |
drastically reduced the dioxygenase activity |
676846 |
| 1.13.11.52 | F227A |
drastically reduced the dioxygenase activity |
676846 |
| 1.13.11.52 | G261A |
site-directed mutagenesis, mutation of a loop residues that connects the hIDO domains |
742005 |
| 1.13.11.52 | G261V |
site-directed mutagenesis, mutation of a loop residues that connects the hIDO domains |
742005 |
| 1.13.11.52 | H16A |
does not act as proximal ligand |
659233 |
