EC Number   |
Protein Variants |
Reference |
|---|
    1.1.1.188 | C44S |
retains 63% of the enzyme activity of the wild-type |
687797 |
| 1.1.1.188 | C44S/C47S |
shows values below 1% of the enzyme activity of the wild-type |
687797 |
| 1.1.1.188 | C47S |
shows values below 1% of the enzyme activity of the wild-type |
687797 |
| 1.1.1.188 | D43E |
only trace activities in presence and absence of NADPH |
724961 |
| 1.1.1.188 | D43N |
only trace activities in presence and absence of NADPH |
724961 |
| 1.1.1.188 | H110A |
only trace activities in presence and absence of NADPH |
724961 |
| 1.1.1.188 | H110F |
only trace activities in presence and absence of NADPH |
724961 |
| 1.1.1.188 | H170C |
fully active |
389449 |
| 1.1.1.188 | H170C |
site-directed mutagenesis, increased Km for prostaglandin PGD2 and 8fold decreased Km for prostaglandin PGH2 compared to the wild-type enzyme |
654159 |
| 1.1.1.188 | K225S |
2fold as active as wild-type |
389449 |
