EC Number   |
|---|
   3.4.22.B80 | 2.85 A crystal structure of SARS PLpro bound to a diUbLys48 activity based probe |
| 3.4.22.B80 | crystallization of apo-form SCov-2 PLproC112S is set up in hanging-drop manner at 16°C |
| 3.4.22.B80 | crystals of SARS-CoV PLpro in complex with 2-mercaptoethanol or glycerol are obtained at 22°C by the sitting-drop vapor-diffusion method |
| 3.4.22.B80 | sitting-drop and hanging drop vapor-diffusion methods, seven crystal structures are reported, including the high-resolution structure of wild-type PLpro, the active site cysteine mutant, and their complexes with inhibitors of SARS-CoV-2 PLpro, determined at 1.60-2.50 A |
| 3.4.22.B80 | sitting-drop vapor-diffusion method at 18°C, crystal structures of the enzyme and its complex with YM155 at 2.1 A resolution |
| 3.4.22.B80 | structure of PLpro in complex with GRL0617, the inhibitor binds within the S4-S3 subsites of the enzyme and induces a loop closure that shuts down catalysis at the active site |
