EC Number |
Ki Value [mM] |
Ki Value maximum [mM] |
Inhibitor |
Reference |
---|
1.5.1.5 | 0.000105 |
- |
(2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazol[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioate |
- |
700281 |
1.5.1.5 | 0.000105 |
- |
(2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazo[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioic acid |
pH 7.3, 27°C, Leishmania wild-type growth is inhibited with an EC50 of 1.1 microM, DHCH1 or formate-tetrahydrofolate ligase overexpressing (FTL) Leishmania transfectants show 4-5fold or 3fold resistance, respectively |
700281 |
1.5.1.5 | 0.000105 |
- |
LY354899 |
pH and temperature not specified in the publication |
720406 |
1.5.1.5 | 0.003 |
- |
dihydropteroylpentaglutamate |
varying concentration of tetrahydropteroylmonoglutamate |
209737 |
1.5.1.5 | 0.035 |
- |
dihydropteroylmonoglutamate |
varying concentration of tetrahydropteroylmonoglutamate |
209737 |
1.5.1.5 | 0.07 |
- |
N10-formyltetrahydrofolate |
- |
392307 |
1.5.1.5 | 0.2 |
- |
NAD+ |
- |
392311 |
1.5.1.5 | 0.34 |
- |
ATP |
- |
392312 |
1.5.1.5 | 0.61 |
- |
pteroylglutamate |
varying concentration of tetrahydropteroylmonoglutamate |
209737 |