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Results 1 - 7 of 7
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EC Number pH Minimum pH Maximum Commentary Reference
Show all pathways known for 1.1.1.145Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.145-999 - metabolic conversion assays indicate peak 3betaHSD2 activity at pH 4.5 with 2fold more progesterone synthesized at pH 4.5 than at pH 3.5 and 7.4. Increasing the 3betaSD2 concentration from 1 to 40 microg results in a 7fold increase in progesterone at pH 4.5, but no change at pH 7.4. At pH 4-5, 3betaHSD2 takes on a molten globule conformation that promotes the dual functionality of the enzyme, i.e. 3 beta-hydroxysteroid dehydrogenase and Delta 5->4-isomerase activity 725511
Show all pathways known for 1.1.1.145Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.1452 12 approx. 50% of maximal activity at pH 4.0 and pH 10.0 657352
Show all pathways known for 1.1.1.145Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.1456.5 10 pH 6.5: about 55% of maximal activity, pH 10.0: about 45% of maximal activity 763139
Show all pathways known for 1.1.1.145Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.1456.8 9 - 389376
Show all pathways known for 1.1.1.145Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.1457.4 - 52% of maximal activity 656091
Show all pathways known for 1.1.1.145Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.1457.4 9.7 37% of maximal activity at pH 7.4 656577
Show all pathways known for 1.1.1.145Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.1457.4 9.7 structure motif-dependent pH dependence, overview 656091
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