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Results 1 - 8 of 8
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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Show all pathways known for 2.5.1.B21Display the reaction diagram Show all sequences 2.5.1.B215'-deoxy-5'-chloroadenosine + H2O adenosine is generated from 5'-deoxy-5'-chloroadenosine with much lower efficiency than from S-adenosyl-L-methionine Pyrococcus horikoshii adenosine + ? - ?
Show all pathways known for 2.5.1.B21Display the reaction diagram Show all sequences 2.5.1.B215'-deoxy-5'-chloroadenosine + H2O adenosine is generated from 5'-deoxy-5'-chloroadenosine with much lower efficiency than from S-adenosyl-L-methionine Pyrococcus horikoshii OT-3 adenosine + ? - ?
Show all pathways known for 2.5.1.B21Display the reaction diagram Show all sequences 2.5.1.B21S-adenosyl-L-methionine + H2O - Salinispora arenicola adenosine + L-methionine + H+ - ?
Show all pathways known for 2.5.1.B21Display the reaction diagram Show all sequences 2.5.1.B21S-adenosyl-L-methionine + H2O the enzyme is most active at pH 8.5, so perhaps it has a regulatory role in influencing the cellular pH in the host organism. Many, but not all of the duf-62 containing organisms are extremophiles Pyrococcus horikoshii adenosine + L-methionine + H+ - ?
Show all pathways known for 2.5.1.B21Display the reaction diagram Show all sequences 2.5.1.B21S-adenosyl-L-methionine + H2O conversion of S-adenosyl-L-methionine into adenosine by the attack of a hydroxide ion from water at C5’ of S-adenosyl-L-methionine. No new products are detected by HPLC or NMR spectroscopy after the incubation of the enzyme with S-adenosyl-L-methionine and F-, Cl-, or NH4+ ions at high mM concentrations. In all cases adenosine is generated in a manner consistent with normal enzymatic turnover, with water providing the nucleophil Pyrococcus horikoshii adenosine + L-methionine + H+ - ?
Show all pathways known for 2.5.1.B21Display the reaction diagram Show all sequences 2.5.1.B21S-adenosyl-L-methionine + H2O mechanistic hypothesis for SAM hydroxide adenosyltransferase Pyrococcus horikoshii adenosine + L-methionine + H+ - ?
Show all pathways known for 2.5.1.B21Display the reaction diagram Show all sequences 2.5.1.B21S-adenosyl-L-methionine + H2O the amino acid Asp-Arg-His triad and particularly the Asp-Arg ion pair appears to play an important role in holding the water for nucleophilic attack as S-adenosyl-L-methionine binds and becomes proximate Pyrococcus horikoshii adenosine + L-methionine + H+ - ?
Show all pathways known for 2.5.1.B21Display the reaction diagram Show all sequences 2.5.1.B21S-adenosyl-L-methionine + H2O conversion of S-adenosyl-L-methionine into adenosine by the attack of a hydroxide ion from water at C5’ of S-adenosyl-L-methionine. No new products are detected by HPLC or NMR spectroscopy after the incubation of the enzyme with S-adenosyl-L-methionine and F-, Cl-, or NH4+ ions at high mM concentrations. In all cases adenosine is generated in a manner consistent with normal enzymatic turnover, with water providing the nucleophil Pyrococcus horikoshii OT-3 adenosine + L-methionine + H+ - ?
Results 1 - 8 of 8
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