EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.5.1.86 | (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate |
- |
Mycobacterium tuberculosis |
diphosphate + decaprenyl diphosphate + nonaprenyl diphosphate + octaprenyl diphosphate |
the relative amounts of both decaprenyl diphosphate and octaprenyl diphosphate are greater than that of nonaprenyl diphosphate. Shorter chain length also produced. As the concentration of (2Z,6E)-farnesyl diphosphate is increased in the assays, there is an increase in the amount of the shorter products synthesized relative to decaprenyl diphosphate |
? |
2.5.1.86 | (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate |
- |
Mycobacterium tuberculosis H37Rv |
diphosphate + decaprenyl diphosphate + nonaprenyl diphosphate + octaprenyl diphosphate |
the relative amounts of both decaprenyl diphosphate and octaprenyl diphosphate are greater than that of nonaprenyl diphosphate. Shorter chain length also produced. As the concentration of (2Z,6E)-farnesyl diphosphate is increased in the assays, there is an increase in the amount of the shorter products synthesized relative to decaprenyl diphosphate |
? |
2.5.1.86 | (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate |
- |
Mycolicibacterium smegmatis |
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate |
- |
? |
2.5.1.86 | (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate |
- |
Mycobacterium tuberculosis |
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate |
- |
? |
2.5.1.86 | (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate |
the catalytic efficiency is greatest when (2Z,6E)-farnesyl diphosphate is used as the allylic acceptor, suggesting that this is the natural substrate in vivo |
Mycobacterium tuberculosis |
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate |
- |
? |
2.5.1.86 | (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate |
the enzyme is involved in decaprenyl phosphate synthesis, that is important in the rate of bacterial growth and the synthesis of cell wall components |
Mycolicibacterium smegmatis |
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate |
- |
? |
2.5.1.86 | (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate |
the enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan |
Mycobacterium tuberculosis |
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate |
- |
? |
2.5.1.86 | (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate |
(2Z,6E)-farnesyl diphosphate i.e. omega, E,Z-farnesyl diphosphate, the catalytic efficiency is greatest when (2Z,6E)-farnesyl diphosphate is used as the allylic acceptor |
Mycobacterium tuberculosis |
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate |
decaprenyl diphosphate is the predominant product synthesized, smaller amounts of intermediates of intermediates of shorter chain lengths also being produced. The amount of 40-carbon and 45-carbon products relative to 50-carbon products increases as the (2Z,6E)-farnesyl diphosphate concentration is increased, suggesting that the enzyme loses specificity as the substrate concentration increases |
? |
2.5.1.86 | (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate |
the catalytic efficiency is greatest when (2Z,6E)-farnesyl diphosphate is used as the allylic acceptor, suggesting that this is the natural substrate in vivo |
Mycobacterium tuberculosis H37Rv |
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate |
- |
? |
2.5.1.86 | (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate |
(2Z,6E)-farnesyl diphosphate i.e. omega, E,Z-farnesyl diphosphate, the catalytic efficiency is greatest when (2Z,6E)-farnesyl diphosphate is used as the allylic acceptor |
Mycobacterium tuberculosis H37Rv |
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate |
decaprenyl diphosphate is the predominant product synthesized, smaller amounts of intermediates of intermediates of shorter chain lengths also being produced. The amount of 40-carbon and 45-carbon products relative to 50-carbon products increases as the (2Z,6E)-farnesyl diphosphate concentration is increased, suggesting that the enzyme loses specificity as the substrate concentration increases |
? |