EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.5.1.63 | 2'-deoxy-2-ethynyladenosyl-L-methionine + fluoride |
- |
Streptomyces sp. MA37 |
2'-deoxy-2-ethynyl-5'-fluoroadenosine + L-methionine |
- |
r |
2.5.1.63 | 2'-deoxyadenosyl-L-methionine + fluoride |
- |
Streptomyces cattleya |
2'-deoxy-5'-fluoroadenosine + L-methionine |
- |
r |
2.5.1.63 | 2'-deoxyadenosyl-L-methionine + fluoride |
- |
Streptomyces sp. MA37 |
2'-deoxy-5'-fluoroadenosine + L-methionine |
- |
? |
2.5.1.63 | 2'-deoxyadenosyl-L-methionine + fluoride |
- |
Streptomyces cattleya |
2'-deoxy-5'-fluoroadenosine + L-methionine |
in the reverse reaction the enzyme shows 10% activity with the 2'-deoxy compound compared to the activity with the 5'-derivative |
r |
2.5.1.63 | 2'-deoxyadenosyl-L-methionine + fluoride |
C-F bond formation, substrate binding structure, NMR and mass spectrometry, overview |
Streptomyces cattleya |
2'-deoxy-5'-fluoroadenosine + L-methionine |
in the reverse reaction the enzyme shows 10% activity with the 2'-deoxy compound compared to the activity with the 5'-derivative |
r |
2.5.1.63 | 5'-deoxy-5'-chloroadenosine + L-methionine |
- |
Streptomyces sp. MA37 |
S-adenosyl-L-methionine + chloride |
- |
r |
2.5.1.63 | 5'-deoxy-5'-chloroadenosine + L-selenomethionine |
use of L-selenomethionine increases the yield by around 2fold |
Streptomyces sp. MA37 |
S-adenosyl-L-selenomethionine + chloride |
- |
r |
2.5.1.63 | 5'-deoxy-5'-fluoroadenosine + L-selenomethionine |
- |
Streptomyces cattleya |
Se-adenosyl-L-selenomethionine + fluoride |
- |
r |
2.5.1.63 | 5-deoxy-5'-bromoadenosine + fluoride |
- |
Streptomyces cattleya |
5-deoxy-5'-fluoroadenosine + bromide |
- |
r |
2.5.1.63 | 5-deoxy-5'-chloroadenosine + L-methionine |
- |
Streptomyces cattleya |
S-adenosyl-L-methionine + chloride |
- |
r |