EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.5.1.5 | (6R,S)-5,10-methylenetetrahydrofolate + NADP+ |
monofunctional enzyme, no methenyltetrahydrofolate cyclohydrolase activity |
Clostridium perfringens |
5,10-methenyltetrahydrofolate + NADPH + H+ |
- |
? |
1.5.1.5 | 5,10-methylene tetrahydrofolate + NAD+ |
bifunctional enzyme exhibits dehydrogenase and cyclohydrogenase activities |
Homo sapiens |
5,10-methenyl tetrahydrofolate + NADH + H+ |
- |
r |
1.5.1.5 | 5,10-methylene tetrahydrofolate + NADP+ |
trifunctional enzyme exhibits synthetase, dehydrogenase and cyclohydrolase activities |
Saccharomyces cerevisiae |
5,10-methenyl tetrahydrofolate + NADPH |
- |
r |
1.5.1.5 | 5,10-methylene tetrahydrofolate + NADP+ |
DH activity |
Leishmania major |
5,10-methenyl tetrahydrofolate + NADPH + H+ |
- |
r |
1.5.1.5 | 5,10-methylene tetrahydrofolate + NADP+ |
trifunctional enzyme exhibits synthetase, dehydrogenase and cyclohydrogenase activities |
Homo sapiens |
5,10-methenyl tetrahydrofolate + NADPH + H+ |
- |
r |
1.5.1.5 | 5,10-methylene tetrahydrofolate + NADP+ |
dehydrogenase activity of MTHFD1 |
Homo sapiens |
5,10-methenyltetrahydrofolate + NADPH |
- |
r |
1.5.1.5 | 5,10-methylene-tetrahydrofolate + NAD+ |
combined cofactors NAD+, Mg2+, and phosphate mimic the binding of NADP+ in NADP(+)-dependent dehydrogenase |
Homo sapiens |
5,10-methenyl-tetrahydrofolate + NADH |
50-60% channeled to the cyclohydrolase to form formyltetrahydrofolate |
r |
1.5.1.5 | 5,10-methylene-tetrahydrofolate + NADP+ |
- |
Leishmania major |
5,10-methenyl-tetrahydrofolate + NADPH + H+ |
10-formyl tetrahydrofolate (10-CHO-THF)is the product of subsequently active methenyltetrahydrofolate cyclohydrolase, ATP-dependent formate-tetrahydrofolate ligase catalyzes an alternative one step reaction from tetrahydrofolate + format to 10-formyl tetrahydrofolate |
? |
1.5.1.5 | 5,10-methylene-tetrahydrofolate + NADP+ |
- |
Homo sapiens |
5,10-methenyl-tetrahydrofolate + NADPH + H+ |
the cyclohydrolase forms formyltetrahydrofolate |
r |
1.5.1.5 | 5,10-methylenetetrahydrofolate + NAD+ |
- |
Bombyx mori |
5,10-methenyltetrahydrofolate + NADH + H+ |
- |
? |