EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.3.1.1 | 5,6-dihydrouracil + NAD+ |
- |
Homo sapiens |
uracil + NADH + H+ |
- |
r |
1.3.1.1 | 5,6-dihydrouracil + NAD+ |
- |
Escherichia coli |
uracil + NADH + H+ |
- |
? |
1.3.1.1 | 5-fluorouracil + NAD+ |
- |
Homo sapiens |
? + NADH |
- |
r |
1.3.1.1 | 5-fluorouracil + NAD+ |
rate-limiting step in the elimination of the chemotherapeutic drug fluoropyrimidine |
Homo sapiens |
? + NADH |
- |
r |
1.3.1.1 | 5-fluorouracil + NAD+ |
- |
Homo sapiens |
alpha-fluoro-beta-alanine + NADH + H+ |
- |
? |
1.3.1.1 | 5-fluorouracil + NADH + H+ |
- |
Homo sapiens |
5-fluoro-5,6-dihydrouracil + NAD+ |
- |
? |
1.3.1.1 | 5-fluorouracil + NADH + H+ |
- |
Caenorhabditis elegans |
5-fluoro-5,6-dihydrouracil + NAD+ |
- |
? |
1.3.1.1 | 5-fluorouracil + NADH + H+ |
- |
Escherichia coli |
5-fluoro-5,6-dihydrouracil + NAD+ |
- |
r |
1.3.1.1 | 5-fluorouracil + NADH + H+ |
- |
Homo sapiens |
5-fluoro-5,6-dihydrouracil + NAD+ |
dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine |
? |
1.3.1.1 | 5-fluorouracil + NADH + H+ |
dihydropyrimidine dehydrogenase is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil |
Homo sapiens |
5-fluoro-5,6-dihydrouracil + NAD+ |
- |
? |