EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
6.2.1.1 | acetate-CoA ligase |
brain |
- |
562, 563, 572 |
6.2.1.15 | arachidonate-CoA ligase |
brain |
microvessels |
635, 644 |
6.2.1.15 | arachidonate-CoA ligase |
brain |
- |
640, 646 |
6.2.1.17 | propionate-CoA ligase |
brain |
- |
658 |
6.2.1.2 | medium-chain acyl-CoA ligase |
brain |
- |
658 |
6.2.1.2 | medium-chain acyl-CoA ligase |
brain |
major activity |
670 |
6.2.1.3 | long-chain-fatty-acid-CoA ligase |
brain |
low activity |
733 |
6.2.1.3 | long-chain-fatty-acid-CoA ligase |
brain |
most abundant in |
740 |
6.2.1.5 | succinate-CoA ligase (ADP-forming) |
brain |
- |
693488, 744272, 803, 819 |
6.3.2.11 | carnosine synthase |
brain |
- |
1002, 699007, 744004, 988, 989, 995, 996, 997 |
6.3.2.11 | carnosine synthase |
brain |
frontal and temporal cortex, activity decreases rapidly after brain death |
991 |
6.3.2.25 | tubulin-tyrosine ligase |
brain |
- |
1166, 1167, 1168, 1170, 1172, 1173, 1174, 1175, 1177, 1178, 1179, 1180, 1182, 1183, 1184, 686295 |
6.3.3.2 | 5-formyltetrahydrofolate cyclo-ligase |
brain |
low activity |
1327 |
6.3.5.2 | GMP synthase (glutamine-hydrolysing) |
brain |
- |
1354, 1384 |
6.3.4.4 | adenylosuccinate synthase |
brain |
- |
1537 |
6.3.4.5 | argininosuccinate synthase |
brain |
- |
1594 |
6.3.5.3 | phosphoribosylformylglycinamidine synthase |
brain |
- |
1664 |
6.3.5.4 | asparagine synthase (glutamine-hydrolysing) |
brain |
low |
1710 |
6.3.5.4 | asparagine synthase (glutamine-hydrolysing) |
brain |
- |
1712 |
6.3.5.5 | carbamoyl-phosphate synthase (glutamine-hydrolysing) |
brain |
- |
1743 |
5.1.3.8 | N-acylglucosamine 2-epimerase |
brain |
- |
2269 |
5.3.1.21 | corticosteroid side-chain-isomerase |
brain |
- |
2655 |
5.3.1.6 | ribose-5-phosphate isomerase |
brain |
two electrophorectic forms |
2777 |
5.3.1.8 | mannose-6-phosphate isomerase |
brain |
- |
2826 |
5.3.3.2 | isopentenyl-diphosphate DELTA-isomerase |
brain |
- |
2933 |
5.3.3.8 | DELTA3-DELTA2-enoyl-CoA isomerase |
brain |
weakly expressed |
3009 |
5.3.4.1 | protein disulfide-isomerase |
brain |
activities in adult tissues are only 10-40% of those found in newborn |
3049 |
5.3.4.1 | protein disulfide-isomerase |
brain |
lowest activity of the tissues tested |
3049 |
5.3.99.2 | Prostaglandin-D synthase |
brain |
cellular localization of the enzyme changes postnatally. The enzyme is distributed in most neurons of the brain of 1-2 week old rats, whereas it is localized in the oligodendrocytes of adult animals |
3102 |
5.3.99.2 | Prostaglandin-D synthase |
brain |
prostaglandin-H2 D-isomerase is produced in the membrane system surrounding the brain and is secreted into the cerebrospinal fluid to become beta-trace |
3106 |
5.3.99.2 | Prostaglandin-D synthase |
brain |
glutathione-independent enzyme |
3121 |
5.3.99.5 | thromboxane-A synthase |
brain |
- |
3183 |
5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) |
brain |
distribution in normal brain, astrocytomas, anaplastic astrocytomas, glioblastomas, meningiomas, no difference in subunit-type in normal and tumor brain cells |
3217 |
5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) |
brain |
regional distribution |
3217 |
5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) |
brain |
in tumor cells the amount of EC 5.4.2.1 is decreased compared to normal cells |
3218 |
5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) |
brain |
distribution of BB-type MB-type and MM-type iszozymes |
3220 |
5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) |
brain |
- |
3235, 3236, 3261, 705270, 748795 |
5.4.3.7 | leucine 2,3-aminomutase |
brain |
- |
3411, 3413, 3415 |
5.5.1.4 | inositol-3-phosphate synthase |
brain |
fetal and adult |
3693 |
5.5.1.4 | inositol-3-phosphate synthase |
brain |
- |
3700, 3706, 682259, 746709 |
5.5.1.4 | inositol-3-phosphate synthase |
brain |
adult |
3704 |
5.5.1.4 | inositol-3-phosphate synthase |
brain |
fetal |
3704, 3706 |
4.1.1.12 | aspartate 4-decarboxylase |
brain |
highest activity in the cortex, lowest activity in the striatum and hippocampus |
3961 |
4.1.1.15 | glutamate decarboxylase |
brain |
- |
-, 3971, 3974, 3975, 3979, 3980, 3981, 3983, 3984, 3988, 3989, 3991, 3992, 3995, 3996, 654858, 655982, 656454, 656868, 675530, 695988, 696820, 697040, 697049, 697617, 697807, 698395, 699647, 699668, 699674, 699881, 699924, 700110, 700429, 700470, 700471, 700472, 700956, 706836, 748691 |
4.1.1.17 | ornithine decarboxylase |
brain |
- |
4006, 680257, 696087 |
4.1.1.19 | arginine decarboxylase |
brain |
- |
4097, 681527, 692560, 747036 |
4.1.1.22 | histidine decarboxylase |
brain |
- |
-, 4144, 4160, 4161, 4162, 749082 |
4.1.1.28 | aromatic-L-amino-acid decarboxylase |
brain |
cerebellum |
4200, 4227 |
4.1.1.28 | aromatic-L-amino-acid decarboxylase |
brain |
hypothalamus |
4200, 4227 |
4.1.1.28 | aromatic-L-amino-acid decarboxylase |
brain |
midbrain |
4200 |
4.1.1.28 | aromatic-L-amino-acid decarboxylase |
brain |
brain stem |
4222, 4227 |
4.1.1.28 | aromatic-L-amino-acid decarboxylase |
brain |
cerebral cortex |
4227 |
4.1.1.28 | aromatic-L-amino-acid decarboxylase |
brain |
hippocampus |
4227 |
4.1.1.29 | sulfinoalanine decarboxylase |
brain |
- |
-, 3979, 4236, 4238, 4239, 4243, 4257, 746903, 748047 |
4.1.1.29 | sulfinoalanine decarboxylase |
brain |
cerebellum, medulla oblongata, pons, hypothalamus, striatum, midbrain, hippocampus, cerebral cortex |
4242 |
4.1.1.29 | sulfinoalanine decarboxylase |
brain |
cerebellum |
4243 |
4.1.1.29 | sulfinoalanine decarboxylase |
brain |
astrocytes in the cerebellum and hippocampus |
4247 |
4.1.1.29 | sulfinoalanine decarboxylase |
brain |
strictly localized in astrocytes in the cerebellum and in the hippocampus |
4248 |
4.1.1.29 | sulfinoalanine decarboxylase |
brain |
immunocytochemical visualization of sulfinoalanine decarboxylase with a specific antiserum |
4251 |
4.1.1.29 | sulfinoalanine decarboxylase |
brain |
glial localization in cerebellum |
4255 |
4.1.1.112 | oxaloacetate decarboxylase |
brain |
- |
4270 |
4.1.1.40 | hydroxypyruvate decarboxylase |
brain |
- |
4542 |
4.1.1.53 | phenylalanine decarboxylase |
brain |
- |
4704, 4705 |
4.1.1.65 | phosphatidylserine decarboxylase |
brain |
- |
4776 |
4.1.1.9 | malonyl-CoA decarboxylase |
brain |
- |
4844, 4846, 727260 |
4.1.1.9 | malonyl-CoA decarboxylase |
brain |
contains less than 1% of the malonyl-CoA decarboxylase mRNA in the gland |
4861 |
4.1.1.9 | malonyl-CoA decarboxylase |
brain |
nerve cells of the cerebral cortex, microglia, Golgi epithelial cells, Bergmann glia cells. Activity in brain is low, but steadily increases after birth. No activity in neurons of the cerebellar cortex |
4862 |
2.7.1.3 | ketohexokinase |
brain |
- |
4933, 760194 |
4.1.2.13 | fructose-bisphosphate aldolase |
brain |
- |
4933, 4941, 666852, 682111, 693713 |
4.1.2.27 | sphinganine-1-phosphate aldolase |
brain |
- |
5112, 5119, 5122, 682957, 748220 |
4.1.3.16 | 4-Hydroxy-2-oxoglutarate aldolase |
brain |
poor activity |
5237 |
4.1.3.4 | hydroxymethylglutaryl-CoA lyase |
brain |
- |
5364 |
1.5.1.11 | D-octopine dehydrogenase |
brain |
- |
13301, 13312 |
2.3.1.147 | glycerophospholipid arachidonoyl-transferase (CoA-independent) |
brain |
- |
16268 |
3.4.17.22 | metallocarboxypeptidase D |
brain |
- |
28967 |
3.4.21.53 | Endopeptidase La |
brain |
hippocampus, human |
29357 |
3.4.21.93 | Proprotein convertase 1 |
brain |
- |
29871, 669904, 683932 |
3.4.24.61 | nardilysin |
brain |
cerebral cortex, enzyme is catalytically and immunologically related to testis enzyme |
31365 |
3.4.24.61 | nardilysin |
brain |
- |
31366, 31367, 31369, 31370, 667791, 669940, 733071, 734781 |
4.1.3.3 | N-acetylneuraminate lyase |
brain |
- |
33330 |
2.3.3.8 | ATP citrate synthase |
brain |
- |
33352, 488193 |
4.2.1.1 | carbonic anhydrase |
brain |
carbonic anhydrase IV |
33573 |
4.2.1.11 | phosphopyruvate hydratase |
brain |
- |
3235, 33611, 33612, 33615, 33621, 33624, 33629, 33638, 666023, 666463, 705257 |
4.2.1.11 | phosphopyruvate hydratase |
brain |
enolase I (alpha,alpha-enolase), enolase II (alpha,gamma-enolase), enolase III (gamma,gamma-enolase) |
33613, 33614 |
4.2.1.11 | phosphopyruvate hydratase |
brain |
the brain alpha,gamma and gamma,gamma forms are not detectable in the early embryonic stage and increase gradually during the development of the brain, whereas the alpha,alpha form exists at an almost constant level during development |
33614 |
4.2.1.3 | aconitate hydratase |
brain |
- |
33808 |
4.3.2.3 | ureidoglycolate lyase |
brain |
- |
34477 |
4.4.1.1 | cystathionine gamma-lyase |
brain |
enzyme activity remains low during all stages of development |
34497 |
4.6.1.1 | adenylate cyclase |
brain |
cerebral cortex |
34761 |
4.6.1.1 | adenylate cyclase |
brain |
mictrotubule |
34762 |
4.6.1.1 | adenylate cyclase |
brain |
- |
-, 34759, 34783, 34788, 34794, 34797, 34801, 34807, 34815, 34816, 34825, 678070, 679129, 679659, 680097, 681587, 682136, 690680, 691173, 691561, 693293, 693750, 693760, 693830, 694376, 694874, 710114, 715176, 729827 |
4.6.1.1 | adenylate cyclase |
brain |
hippocampus, cerebellum and neocortex |
34807 |
4.6.1.1 | adenylate cyclase |
brain |
striatum |
34809 |
4.6.1.2 | guanylate cyclase |
brain |
myelin |
34871 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
brain |
accounts for about 2% of soluble protein in brain |
35003 |
3.4.13.5 | Xaa-methyl-His dipeptidase |
brain |
very rich source |
35025 |
3.4.11.5 | prolyl aminopeptidase |
brain |
- |
35966 |
3.4.11.9 | Xaa-Pro aminopeptidase |
brain |
- |
36043, 36057 |
3.4.13.5 | Xaa-methyl-His dipeptidase |
brain |
all regions of the brain except for the spinal cord and the optic nerve |
36081 |
3.4.13.9 | Xaa-Pro dipeptidase |
brain |
- |
36094, 683958, 707010 |