EC Number   |
General Information |
Reference |
|---|
    3.5.1.2 | evolution |
the enzyme belongs to a distinct type of glutaminase with an amidase signature sequence forming a distinct family |
-, 719119 |
| 3.5.1.2 | malfunction |
treating cells that coexpressed Mek2-K101A and kidney-type glutaminase with suboptimal level of BPTES leads to synergistic inhibition on cell proliferation |
720942 |
| 3.5.1.2 | metabolism |
glutaminase C is the first enzyme in glutaminolysis |
720930 |
| 3.5.1.2 | more |
Ile221-Leu533 is the catalytic domain of kidney-type glutaminase |
720942 |
| 3.5.1.2 | physiological function |
GLS2 identified as a previously uncharacterized p53 target gene to regulate cellular energy metabolism and antioxidant defense. GLS regulates cellular energy metabolism by increasing production of glutamate and 2-oxoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. Furthemore GLS2 regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing reactive oxygen spcies (ROS) levels, which in turn protects cells from oxidative stress |
713428 |
| 3.5.1.2 | physiological function |
GLS2 probably controls the intracellular reactive oxygen species (ROS) and the apoptotic response fascilitating the ability of p53 to protect cells from accumulation of genomic damage and allows cells to survive after mild and repairable genotoxic stress |
713429 |
| 3.5.1.2 | physiological function |
glutaminase C is important for tumor metabolism. Glutamate production by mitochondrial glutaminase C, the first enzyme in glutaminolysis, is a key process for body homeostasis, and a crucial carbon donor for amino acid and lipid synthesis in tumor cells |
720930 |
| 3.5.1.2 | physiological function |
glutaminase functions in cellular metabolism of every organism by supplying nitrogen required for the biosynthesis of a variety of metabolic intermediates, while glutamic acid plays a role in both sensory and nutritional properties of food |
-, 720975 |
| 3.5.1.2 | physiological function |
kidney-type glutaminase activity in cells is stimulated by EGF, and kidney-type glutaminase associates with all three kinase components of the Raf-1/Mek2/Erk signaling module, interaction mode, the bound ligand makes several hydrogen-bonding contacts to Gln285, Ser286, Asn335, Glu381, Asn388, Tyr414, Tyr466, and Val484, overview. The kidney-type glutaminase active and inhibitory sites show a dynamic nature, cross-talk and regulation of kidney-type glutaminase activities by EGF-mediated Raf-Mek-Erk signaling. The enhanced activity is abrogated by kinase-dead, dominant negative mutants of Raf-1 (Raf-1-K375M) andMek2 (Mek2-K101A), protein phosphatase PP2A, and Mek-inhibitor U0126, indicative of phosphorylation-dependent regulation. kidney-type glutaminase can interact equally well with the wild-type or mutant forms of Raf-1 and Mek2. The activity of kidney-type glutaminase is directly regulated by Raf-Mek-Erk downstream of EGF receptor |
720942 |
