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EC Number	General Information	Commentary	Reference
2.1.1.B128	evolution	the N1-methyladenosine in helix 25.1 of 25/28S rRNA seems to be highly conserved	758419
2.1.1.B128	malfunction	siRNA-mediated depletion of NML is highly efficient at mRNA level, impact of an NML knockdown on m1A1322 methylation in HCT-116 cells. Depletion of NML leads to abnormal and altered nucleolar morphology	758419
2.1.1.B128	physiological function	the human nucleomethylin (NML or RRP8) fails to complement the pre-rRNA processing phenotype and the growth cold sensitivity of Saccharomyces cerevisiae DELTArrp8 mutant strain	758419

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Release 2023.1 (January 2023)