EC Number   |
General Information |
Reference |
|---|
   1.6.2.4 | drug target |
the cytotoxicity of heteroaromatic N-oxides in murine hepatoma MH22a and human colon carcinoma HCT-116 cells increases with the geometric average of their reactivity towards NADPH:cytochrome P-450 reductase and and Plasmodium falciparum ferredoxin:NADP+ oxidoreductase, and with their reactivity towards rat NQO1 |
764913 |
| 1.6.2.4 | evolution |
chicken POR shares high homology with other vertebrates PORs and possesses the conserved binding domains of FAD, FMN, and NADPH |
724797 |
| 1.6.2.4 | evolution |
grouping of dual Cytochrome P450 reductases, CPRs, is in accordance with class I and class II of eudicotyledon CPRs, overview |
726325 |
| 1.6.2.4 | evolution |
Spodoptera littoralis P450s belong to four clades defined by their conservation with vertebrate P450s and their cellular localization |
725134 |
| 1.6.2.4 | evolution |
the enzyme is a member of the diflavin oxidoreductase family. They are multi-domain enzymes containing distinct FAD and FMN domains connected by a flexible hinge. The protein has evolved by fusing two ancestral genes that encode proteins related to a FMN-containing flavodoxin and a FAD-containing ferredoxin-NADP+ oxidoreductase |
724127 |
| 1.6.2.4 | malfunction |
human patients with severe forms of CYPOR mutation show bone defects such as cranio- and humeroradial synostoses and long bone fractures, known as Antley-Bixler-like syndrome, ABS |
724179 |
| 1.6.2.4 | malfunction |
mutations in POR may reduce heme oxygenase-1 activity, potentially influencing heme catabolism in individuals carrying mutant POR alleles |
711112 |
| 1.6.2.4 | malfunction |
the down-regulation of enzyme contributes to an increase of the susceptibility to fenpropathrin in resistant mites |
743799 |
| 1.6.2.4 | metabolism |
human P450 1A2 and 2A6 are able to successfully catalyze the O-deethylation of 7-ethoxyresorufin and the 7-hydroxylation of coumarin, respectively, with the support of the purified enzyme NPR. Purified NPR is an orthologous reductase protein that supports cytochrome P450 enzymes in Malassezia globosa |
725687 |
| 1.6.2.4 | metabolism |
involvement of the enzyme in the withanolide biosynthesic pathway, overview |
726325 |
