EC Number   |
Expression |
Reference |
|---|
    3.5.1.2 | down |
GLS2 expression is reduced in liver tumors |
713429 |
| 3.5.1.2 | more |
GLS2 expression is lost or greatly decreased in hepatocellular carcinomas and the overexpression of GLS2 greatly reduces tumor cell colony formation |
713428 |
| 3.5.1.2 | up |
is induced in response to DNA damage or oxidative stress in a p53-dependent manner, and p53 associates with the GLS promotor |
713429 |
| 3.5.1.2 | up |
isoforms GAB and KGA protein expression levels are higher in human hepatoma HepG2 and lung carcinoma A549 cells than those in fibroblast cell lines Detroit 551 and WI-38, whilst isoform GAC expression levels are not significantly changed |
734818 |
| 3.5.1.2 | up |
maximal production of both enzymes is observed at 37°C, pH 5.0 and 96 h incubation time in solid state fermentation with wheat bran |
-, 752531 |
| 3.5.1.2 | up |
p53 increases the GLS2 expression under both nonstressed and stressed conditions |
713428 |
| 3.5.1.2 | up |
wild-type TrpG shows no constitutive activity and needs to be induced by TrpE |
718925 |
