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EC Number Expression Commentary Reference
Show all pathways known for 1.5.1.5Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.5up the expression level of MTHFD1 is significantly overexpressed in tumor tissues compared to the normal controls in both GSE6631 and TCGA HNSCC cohort. A total of 121 significantly altered IRMEs are identified between head and neck squamous cell carcinoma (HNSCC) and normal tissues, and 21 IRMEs are found to be strongly associated with overall survival of HNSCC. Upregulation of MTHFD1 is positively correlated with adverse clinicopathological factors in TCGA HNSCC cohort. Increased MTHFD1 expression is negatively associated with NK cells activation, while positively correlated with mast cells activation 764552
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