EC Number   |
Expression |
Reference |
|---|
    1.13.11.52 | down |
arachinoate and the prostaglandin metabolite, PGD2, repress the IFNgamma mediated activity of IDO-1 in THP-1 cells and human monocytes |
743716 |
| 1.13.11.52 | down |
IDO expression is abrogated by the heme oxygenase inhibitor zinc protoporphrin (5 mg/kg, i.p.). Heme oxygenase-1 downregulation decreases lipopolysaccharide-induced IDO expression in murine dendritic cells. Lipopolysaccharide induces high IDO expression |
711165 |
| 1.13.11.52 | down |
IDO expression is negatively regulated by interleukin-4, nitric oxide and transforming growth factor-beta |
711952 |
| 1.13.11.52 | down |
in mice heterozygous for the alpha-isoform of calcium/calmodulin-dependent protein kinase II, in which dentate gyrus granule cells fail to mature normally, TDO immunoreactivity is substantially downregulated in the dentate gyrus granule cells |
713002 |
| 1.13.11.52 | down |
sodium butyrate down-regulates indoleamine 2,3-dioxygenase at the transcriptional and post-transcriptional levels. Treatment with sodium butyrate (up to 0.2 mM) significantly reduces IDO induction, which is almost completely inhibited at a concentration of 0.5 mM. Sodium butyrate causes a ubiquitin-mediated proteasomal degradation process that contributes to degradation of IDO. Treatment with bortezomib significantly represses sodium butyrate-induced down-regulation of IDO protein |
712173 |
| 1.13.11.52 | down |
the methanol extracts of Myoga flower buds, which are traditional Japanese foods, and labdane-type diterpene galanal derived from Myoga flowers significantly suppress IDO1 activity |
743654 |
| 1.13.11.52 | more |
IDO expression is not induced by interferon-alpha |
712906 |
| 1.13.11.52 | more |
suppressive effect of plant extracts or phytochemicals on IDO1 induction and activity |
743654 |
| 1.13.11.52 | up |
IDO activity is increased during severe sepsis and septic shock and is associated with mortality. IDO activity is maximal in culture after 3 days of interferon-gamma stimulation |
712647 |
| 1.13.11.52 | up |
IDO expression in bone marrow-derived dendritic cells is increased by hemin, a potent inducer of heme oxygenase-1 |
711165 |
