EC Number   |
Expression |
Reference |
|---|
    1.13.11.31 | down |
level of 12-LOX expression is dose-dependently decreased by UVB and UVA-irradiation. Successful psoralen plus ultraviolet A, UVA-photochemotherapy-mediated inhibition of cell growth and inflammation via decreased 12-LOX expression. 15(S)-hydroxyeicosatetraenoic acid, 15-HETrE and 13(S)-hydroxyoctadecadienoic acid (15-LOX metabolites) significantly inhibit insulin-like growth factor II-induced 12-LOX expression |
703699 |
| 1.13.11.31 | down |
reduced monocyte chemoattractant protein-1 expression in mouse peritoneal macrophages from 12/15-LO null mice |
-, 684350 |
| 1.13.11.31 | down |
siRNA decreases 12-LOX protein expression and hydroxyl radical signals occur in a 12-LOX small interfering RNA knockdown protein group compared with the baicalein control |
703805 |
| 1.13.11.31 | more |
expression of ALOX12 remains on the same level during differentiation from monocyte to macrophage |
726846 |
| 1.13.11.31 | up |
12/15-LO is upregulated in white adipose tissue in the obese state. The potent vasoconstricting and pro-inflammatory hormone angiotensin II (Ang II) led to increases in leukocyte-type 12-LO mRNA and protein levels, as well as increased enzyme activity |
743718 |
| 1.13.11.31 | up |
12/15-LOX activity is enhanced during chronic, but not acute, toxoplasmosis |
-, 704003 |
| 1.13.11.31 | up |
12/15-LOX is markedly upregulated in heart failure, cardiac expression is upregulated during pressure overload |
704901 |
| 1.13.11.31 | up |
12/15-LOX mRNA expression in cultured aortic smooth muscle cells is upregulated by angiotensin II, ATII. ATII also stimulates production of LOX-derived HETEs in arterial vessels and the kidney |
742000 |
| 1.13.11.31 | up |
a sharp increase in protein expression of 12/15 lipoxygenase is found in the pancreatic islets of 10-week old db-/- obese diabetic mice compared to 8-week old counterparts |
765699 |
| 1.13.11.31 | up |
ALOX12 expression and its metabolite 12(S)-hydroxyeicosatetraenoic acid are significantly increased in the visceral adipose tissue of type 2 diabetes subjects with body mass index of 21. ALOX12 expression positively correlated with expression of inflammatory genes encoding IL-6, IL-12a, CXCL10, and lipocalin-2 |
742976 |
