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EC Number Expression Commentary Reference
Show all pathways known for 1.13.11.11Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.11up expression is strongly increased in synovial tissue and fibroblast-like synoviocytes of rheumatoid arthritis and adjuvant-induced arthritis. Immune cells express high amount of the enzyme (TDO2) at the peak stage of adjuvant-induced arthritis 764385
Show all pathways known for 1.13.11.11Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.11up TDO2 gene expression is upregulated in leiomyoma expressing mut-MED12. The tissue mRNA levels of tryptophan 2,3-dioxygenase (TDO2), the rate limiting enzyme of tryptophan metabolism through the kynurenine pathway, is 36fold higher in leiomyomas expressing mutated mediator complex subunit 12 (mut-MED12) compared to adjacent myometrium, and 14fold higher compared to wild type-MED12 leiomyoma 765754
Show all pathways known for 1.13.11.11Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.11up treated with interferon gamma stimulates hIDO1 expression 765516
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