2.3.1.250 | lipoprotein |
primate-specific S-palmitoylation of PORCN at Cys187, fatty acylation of PORCN is not due to autopalmitoylation. The palmitoylation of the enzyme, a membrane-bound O-acyltransferase or MBOAT protein, partially regulates Wnt palmitoylation and signaling, overview. Loss of palmitoylation of PORCN results in a modest increase in Wnt signaling, suggesting a negative regulatory role for PORCN Cys187 fatty acylation |
734745 |