EC Number   |
Application |
Reference |
|---|
    2.4.2.4 | analysis |
methods to measure thymidine and deoxyuridine concentrations and thymidine phosphorylase activity in biological samples. Thymidine phosphorylase activity can be measured by an endpoint determination of the thymine formed after 1 h incubation of the buffy coat homogenate in the presence of a large excess of its substrate thymidine, either spectrophotometrically or by HPLC-UV. The protocols allow the detection of thymidine phosphorylase dysfunction in patients with mitochondrial neurogastrointestinal encephalomyopathy, MNGIE |
723107 |
| 2.4.2.4 | medicine |
a high level of thymidine phosphorylase gene expression is significantly associated with favorable diagnosis of patients treated with 5-fluorouracil-based chemotherapy |
684231 |
| 2.4.2.4 | medicine |
because pancreatic cancer is sensitive to 5-fluorouracil, thymidine phosphorylase-activated oral drug capecitabine in tumoral and endothelial cells and tumor infiltrating thymidine phosphorylase-positive macrophages could increase the concentration of 5-fluorouracil at tumor site, thus resulting in an enhanced antitumor activity |
673961 |
| 2.4.2.4 | medicine |
dThdPase plays an important role in tumor angiogenesis in ductal adenocarcinoma of the pancreas |
686997 |
| 2.4.2.4 | medicine |
expression of PD-ECGF/TP may play an important role in the progression of solid tumors, and inhibitors of thymidine phosphorylase and analogs of the degradation products of thymidine may suppress the growth of tumors by promoting apoptosis |
673635 |
| 2.4.2.4 | medicine |
expression of thymidine phosphorylase mRNA is a useful predictive parameter for the survival of postoperative gastric cancer patients after 5-fluorouracilbased adjuvant chemotherapy |
690197 |
| 2.4.2.4 | medicine |
gliostatin and vascular endothelial growth factor have synergistic effects on angiogenesis in rheumatoid synovitis |
690021 |
| 2.4.2.4 | medicine |
immunhistochemical evaluation of thymidine phosphorylase expression is a promising predictor of therapeutic benefit from docetaxel-modulated capecitabine for metastatic breast cancer |
684458 |
| 2.4.2.4 | medicine |
important target enzyme for cancer chemotherapy |
675107 |
| 2.4.2.4 | medicine |
in gastric cancer, thymidine phosphorylase expression of the cancer cells, not stromal cells may play an important role in tumor growth by microvessel formation |
689292 |
