EC Number   |
Application |
Reference |
|---|
    1.1.1.188 | drug development |
prostaglandin formation is a key component of PGaction and the specific target of non-steroidal anti-inflammatory drugs |
741357 |
| 1.1.1.188 | medicine |
AKR1C3 likely plays important roles in the development of hormone-dependent, and possibly hormone-independent, breast cancer. It is highly expressed in normal breast and upregulated in breast cancer, where its expression is associated with a worse prognosis |
697271 |
| 1.1.1.188 | medicine |
estradiol causes a short-term increase in cyclooxygenase COX-2, which stimulates PGE2 and PGF2alpha secretion, and a subsequent decrease in COX-2 and an increase in cyclooxygenase COX-1 produce a high PGE2 : PGF2alpha ratio |
762365 |
| 1.1.1.188 | medicine |
lentiviral vector-mediated delivery of the prostaglandin F synthase (PGFS) gene resultes in long-term reduction of intraocular pressure and may eliminate off-target tissue effects and the need for daily topical PGF2alpha self-administration |
740341 |
| 1.1.1.188 | medicine |
mice infected with PGFS overexpressing parasites show an early parasitemia peak and higher heart muscle parasitic load |
-, 761141 |
| 1.1.1.188 | medicine |
peri- and postimplantation conceptus. Prostaglandin H synthase and prostaglandin E synthase are down-regulated, and prostaglandin G synthase, prostaglandin F synthase and carbonyl reductase/prostaglandin 9-reductase are down-regulated in conceptuses during trophoblasic elongation. After initiation of implantation, expression of prostaglandin G synthase, prostaglandin F synthase and carbonyl reductase/prostaglandin 9-reductase in conceptuses increases and remains higher until days 24-25 of pregnancy |
688008 |
| 1.1.1.188 | medicine |
significantly higher expression of the prostaglandin-endoperoxide synthase PTGS 2 gene is detected in repeat-breeding cows with subclinical endometritis, whereas there is no significant difference in the expression of prostaglandin F2alpha synthase PTGFS and prostaglandin E2 microsomal synthase mPTGES 1 mRNAs between repeat-breeding cows with subclinical endometritis and those without it |
760315 |
| 1.1.1.188 | molecular biology |
genome editing of human cell lines can be used to complement mouse KO models to validate the function of genes in differentiated tissues and cells |
741012 |
| 1.1.1.188 | pharmacology |
enzyme is a target for cyclooxygenase-independent antineoplastic actions of nonsteroidal anti-inflammatory drugs |
655165 |
| 1.1.1.188 | synthesis |
development of a coupled assay method for enzymatic formation of prostamide F2alpha from anandamide by the cyclooxygenase-II and the prostaglandin synthase F involving the intermediate metabolite, prostamide H2 |
669760 |
