EC Number   |
Natural Substrates |
|---|
   5.6.2.4 | ATP + H2O |
- |
| 5.6.2.4 | ATP + H2O |
3'-5' helicase activity. WRN helicase is involved in preserving DNA integrity during replication. It is proposed that WRN helicase can function in coordinating replication fork progression with replication stress-induced fork remodeling |
| 5.6.2.4 | ATP + H2O |
DNA helicase Hmi1p is involved in the maintenance of mitochondrial DNA |
| 5.6.2.4 | ATP + H2O |
during chromosomal DNA replication, the replicative helicase unwinds the duplex DNA to provide the single-stranded DNA substrate for the polymerase. In archaea, the replicative helicase is the minichromosome maintenance complex. The enzyme utilizes the energy of ATP hydrolysis to translocate along one strand of the duplex and unwind the complementary strand |
| 5.6.2.4 | ATP + H2O |
helicase UvrD protein plays an important role in nucleotide excision repair, mismatch repair, rolling circular plasmid replication, and in DNA replication |
| 5.6.2.4 | ATP + H2O |
helicases play an essential role in nearly all the nucleic acid metabolic processes, catalyzing the transient opening of the duplex nucleic acids in an ATP-dependent manner |
| 5.6.2.4 | ATP + H2O |
involved in DNA recombination, repair and genome stability maintenance |
| 5.6.2.4 | ATP + H2O |
meiosis-specific MER3 protein is required for crossing over, which ensures faithful segregation of homologous chromosomes at the first meiotic division |
| 5.6.2.4 | ATP + H2O |
PcrA is a chromosomally encoded DNA helicase of gram-positive bacteria involved in replication of rolling circle replicating plasmids |
| 5.6.2.4 | ATP + H2O |
the ability of CeWRN-1 to unwind DNA structures may improve the access for DNA repair and replication proteins that are important for preventing the accumulation of abnormal structures, contributing to genomic stability |
