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EC Number Localization Commentary GeneOntology No. Reference
Display the reaction diagram Show all sequences 2.4.1.B64membrane WaaG is membrane-bound, membrane association mechanism, overview. Binding of WaaG to membranes is analyzed by stopped-flow fluorescence and NMR diffusion experiments. Electrostatic interactions are required to bind WaaG to membranes while mere hydrophobic interactions are not sufficient. WaaG senses the membrane's surface charge density but there is no preferential binding to specific anionic lipids. The binding is weaker than expected for monotopic GTs but similar to peripheral GTs. Therefore, WaaG may be a peripheral GT and this can be of functional relevance in vivo since LPS synthesis occurs only when WaaG is membrane-bound. No C-terminal domain movement is observed under the experimental conditions GO:0016020 AmiGO QuickGO 758841
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