EC Number |
Inhibitors |
Structure |
---|
2.3.1.5 | (-)-epigallocatechin-3-O-gallate |
EGCG, non-competitive |
|
2.3.1.5 | (5E)-5-[(4-hydroxy-3,5-diiodophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one |
25fold more selective towards the inhibition of recombinant human NAT1 than N-acetyltransferase 2. Incubation of MDA-MB-231 cell line with (5E)-5-[(4-hydroxy-3,5-diiodophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one results in 60% reduction in NAT1 activity and significant decreases in cell growth, anchorage-dependent growth, and anchorage-independent growth |
|
2.3.1.5 | (5Z)-3-amino-5-(3-hydroxy-2,4-diiodobenzylidene)-2-thioxo-1,3-thiazolidin-4-one |
inhibition of both recombinant enzyme and native enzyme in ZR-75 cell lysate, competitive |
|
2.3.1.5 | (5Z)-5-(2-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one |
i.e. Rhod-o-hp. Significant reduction of cell growth by increasing the percent of MDA-MB-231 cells in G2/M phase of the cell cycle, and reduction of the ability of cells to grow in soft agar |
|
2.3.1.5 | (5Z)-5-(2-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one |
inhibition of both recombinant enzyme and native enzyme in ZR-75 cell lysate, competitive |
|
2.3.1.5 | (5Z)-5-(2-methylbenzylidene)-2-thioxo-1,3-thiazolidin-4-one |
inhibition of both recombinant enzyme and native enzyme in ZR-75 cell lysate, competitive |
|
2.3.1.5 | (5Z)-5-(3,4-dichlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one |
inhibition of both recombinant enzyme and native enzyme in ZR-75 cell lysate, competitive |
|
2.3.1.5 | (5Z)-5-(3-hydroxy-2,4-diiodobenzylidene)-2-thioxo-1,3-thiazolidin-4-one |
inhibition of both recombinant enzyme and native enzyme in ZR-75 cell lysate, competitive |
|
2.3.1.5 | (5Z)-5-(3-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one |
inhibition of both recombinant enzyme and native enzyme in ZR-75 cell lysate, competitive |
|
2.3.1.5 | (5Z)-5-(4-chlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one |
inhibition of both recombinant enzyme and native enzyme in ZR-75 cell lysate, competitive |
|